Searchable abstracts of presentations at key conferences in endocrinology

ea0015p106 | Cytokines and growth factors | SFEBES2008

Expression and purification of the leptin receptor

Carpenter Byron , Wilkinson Ian , Wu Zida , Strasburger Christian , Artymiuk Peter , Ross Richard

Background: Leptin has multiple functions including modulating energy homeostasis and the immune response. Leptin is an important target for therapy to modulate the immune response in several autoimmune diseases. Although the structure of leptin is known, that of its receptor remains unsolved. The aim of this project was to express and purify the extracellular domain the leptin receptor (ObR) in order to carry out functional and crystallisation studies to elucidate the mechani...