Searchable abstracts of presentations at key conferences in endocrinology

ea0015p80 | Clinical practice/governance and case reports | SFEBES2008

An unusually large thyroglossal cyst harbouring a papillary thyroid cancer

Parvanta Laila , Berney Dan , Richards Polly , Akker Scott , Carpenter Robert

A 24-year-old girl was referred with a massive thyroglossal duct cyst (TGDC) and an intra-cystic papillary thyroid cancer (PTC). The impressive clinical photographs, striking radiological images and histology slides are presented.She presented eight and half months post partum with a 10 cm midline neck lump of 4 years duration. She was asymptomatic and was on levothyroxine for Hashimoto’s thyroiditis.Clinically, there was a cy...

ea0031p65 | Clinical practice/governance and case reports | SFEBES2013

Peri-operative α-blockade: efficacy of intravenous phenoxybenzamine vs oral phenoxybenzamine in patients with phaeochromocytoma and paraganglioma

Hussain Shazia , Gunganah Kirun , Ashby Michael , Carpenter Robert , Waterhouse Mona , Druce Maralyn , Drake William , Akker Scott

Introduction: Regimens for pre-operative α and β-blockade for patients with secretory phaeochromocytomas/paragangliomas vary widely between centres. The worldwide lack of availability of intravenous phenoxybenzamine (Goldshield) has removed a useful tool in the management of phaeochromocytoma crisis and has necessitated a change in our institution’s routine pre-operative strategy. We compare pre, peri and post-operative surrogate measures of blockade in a cohort...

ea0028p247 | Pituitary | SFEBES2012

A case series of corticotroph macroadenomas and Cushing’s: clinical characteristics and management

O'Toole Sam , Metcalfe Karl , Plowman Piers , Evanson Jane , Carpenter Robert , Drake Will

Background: Pituitary macroadenomas are an uncommon cause of Cushing’s disease. They present with a higher cortisol burden, are more aggressive and harder to cure and manage than microadenomas.Aims: To review the demographics, clinical features, biochemistry, radiology and required treatment modalities of a single-centre case series of corticotroph macroadenomas.Methods: Retrospective analysis and review of the case records of...

ea0015p74 | Clinical practice/governance and case reports | SFEBES2008

An adrenaline-secreting phaeochromocytoma in pregnancy

Thomas Julia , Vearncombe Laura , Perry Les , Sanghi Anita , Carpenter Robert , Akker Scott

A 37-year-old woman, 30 weeks pregnant, presented with palpitations and abdominal cramps. Ultrasound demonstrated a supra-renal abnormality and MRI showed a 10 cm heterogeneous left adrenal mass. For five years she had experienced episodes of palpitations, shaking, sweating and chest tightness. She was investigated by a neurologist and diagnosed with temporal lobe epilepsy. During pregnancy the frequency of episodes increased. Lamotrigine was started, but at each dose increase...

ea0037ep92 | Adrenal cortex | ECE2015

Long-term outcome from unilateral adrenalectomy in patients with primary aldosteronism

Hannon Mark J , Sze Candy , Carpenter Robert , Parvanta Laila , Matson Matthew , Sahdeve Anju , Druce Maralyn R , Waterhouse Mona , Akker Scott A , Drake William M

Primary aldosteronism (PA) is an important cause of hypertension which confers significant cardiometabolic risk. In approximately half of cases, the cause is a surgically resectable unilateral aldosterone-producing adrenal adenoma, making PA the most common potentially curable form of hypertension. Despite this, long-term data on surgical outcomes that could be used to guide discussions with patients are sparse. Here, we report on clinical outcomes several years post-adrenalec...

ea0056p1160 | Thyroid cancer | ECE2018

Treatment strategies in medullary thyroid carcinoma – outcome following initial surgery with a curative, debulking or prophylactic intent

Mitravela Vasiliki-Ioanna , Glynn Nigel , Waterhouse Mona , Akker Scott , Korbonits Marta , Drake William , Berney Daniel , Plowman Nick , Carpenter Robert , Parvanta Laila , Druce Maralyn

Medullary thyroid carcinoma (MTC) is a rare malignancy which has often metastasised at time of diagnosis. Surgical resection represents the only prospect for cure. However, debulking neck surgery may be beneficial in advanced cases. Prophylactic surgery is increasingly undertaken in asymptomatic patients with known mutations in the RET oncogene. The aim was to describe the outcome following initial surgical treatment for MTC at our institution. We performed a retrospe...