Searchable abstracts of presentations at key conferences in endocrinology

ea0081yi9 | Young Investigator Awards | ECE2022

Acute kidney injury: a strong risk factor for hypoglycaemia in hospitalized patients with type 2 Diabetes

Carreira Ana , Castro Pedro , Mira Filipe , Melo Miguel , Paiva Isabel , Ribeiro Pedro , Santos Lelita

Introduction: Acute Kidney Injury (AKI) is highly prevalent during hospitalization of patients with type 2 diabetes (T2D), and has been associated with increased risk of hypoglycaemia in Intensive Care Units. However, this association in non-critically ill patients is less clear and evidence on the impact of AKI’s severity and duration on hypoglycaemia is lacking.Objectives: To assess the impact of AKI and its severity and duration on the risk of hy...

ea0081ep149 | Calcium and Bone | ECE2022

Bone mineral density in patients with addison disease versus congenital adrenal hyperplasia

Lavrador Mariana , Araujo Barbara Filipa , Carreira Ana , Paiva Sandra , Barros Luisa , Paiva Isabel

Introduction: The treatment of Primary Adrenal Insufficiency involves the chronic use of glucocorticoids. The balance between the dose needed to supply the cortisol deficit and the possible consequences of overtreatment is a challenge. In patients with Addison disease (AD), androgens deficiency is an additional factor for osteoporosis.Objective: To evaluate if there are differences in bone mineral density (BMD) in patients with Addison’s disease ver...

ea0090p308 | Calcium and Bone | ECE2023

Therapeutic Options for Inoperable Local Relapse of Parathyroid Carcinoma with Symptomatic Hypercalcemia: a Case Report

Filipa Araujo Barbara , Carreira Ana , Moreno Carolina , Rodrigues Dircea , Paiva Sandra , Paiva Isabel

Introduction: Parathyroid carcinoma (PC) is an extremely rare malignancy. A complete surgical excision is often difficult, and persistent/recurrent disease occurs in up to 65% of cases. Progression often leads to symptomatic hypercalcemia, the major contributor to poor quality of life and mortality. Treatment options beyond surgical resection are limited. Denosumab is an approved therapy for refractory hypercalcemia of malignancy, and its use in unresectable PC has been descri...

ea0090p692 | Pituitary and Neuroendocrinology | ECE2023

Characterisation of the clinical and biologic behaviour of acromegaly caused by pluri-hormonal tumours in a cohort of 75 patients

Martins Ferreira Mafalda , Carreira Ana , Cardoso Luis , Oliveira Patricia , Melo Miguel , Paiva Isabel

Introduction: The clinical and biochemical spectrum of pituitary acromegaly is wide and variable. There are pure somatotroph tumors(ST), immunohistochemically positive only for GH, and pluri-hormonal(PL), also positive for other hormones, and they appear to have different presentations and responses to treatment.Aims: To compare the clinical presentation, imaging characteristics and response to treatment of acromegalic patients according to the pituitary...

ea0090p267 | Late-Breaking | ECE2023

Surgical outcomes in acromegaly: The influence of sex and menopause

Carreira Ana , Martins Ferreira Mafalda , Cardoso Luis , Guelho Daniela , Gomes Leonor , Melo Miguel , Paiva Isabel

Introduction: Oestrogens and androgens modulate the effects of growth hormone (GH). Sex differences have been described in acromegaly, with conflicting results in different populations. Additionally, data on sex differences in tumour histopathology are scarce.Aims: To analyse the influence of sex and menopause status in tumour characteristics and surgical outcomes in patients with acromegaly.Materials and methods: Retrospective coh...

ea0081p580 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Hypoglycemia and impared hypoglycemia awareness: frequency and relevance in type 1 diabetes under continuous subcutaneous insulin infusion

Mafalda , Carreira Ana , Vieira Ines , Barros Luisa , Melo Miguel , Rodrigues Dircea , Oliveira Patricia , Baptista Carla , Moreno Carolina , Paiva Isabel

Introduction: Continuous subcutaneous insulin infusion (CSII) therapy in type 1 diabetes (T1D) reduces the risk of hypoglycemia. Hypoglycemia remains a treatment-limiting factor. Impared hypoglycemia awareness (IHA) occurs in 25% of T1D cases and seems to be underestimated by continuous glucose monitoring (CGM). Glycemic variability (GV) is a increasingly valued parameter as a predictor of hypoglycemia and risk of chronic complications.Objective: Analysi...

ea0081p590 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Type 1 diabetes on continuous subcutaneous insulin infusion: impact of glycaemic control on quality of life

Carreira Ana , Ferreira Mafalda , Vieira Ines , Lavrador Mariana , Barros Luisa , Baptista Carla , Moreno Carolina , Melo Miguel , Paiva Isabel

Background: In type 1 diabetes (T1D), quality of life (QoL) and the effectiveness of treatment influence each other. QoL has been associated with glycaemic control assessed by HbA1c in T1D on continuous subcutaneous insulin infusion (CSII), but data on the relationship between Continuous Glucose Monitoring (CGM) metrics and QoL are scarce.Objectives: To assess QoL and the association between CGM metrics and QoL in T1D on CSII.Metho...

ea0090p181 | Reproductive and Developmental Endocrinology | ECE2023

In Vitro Fertilization in Polycystic Ovary Syndrome: Treatment Individualization Based on Genetic Singularities

Carreira Ana , Vieira Ines , Reis Sandra , Carvalho Alexandra , Dias Conceicao , Fernandes Silvana , Ferreira Ana , Rodrigues Dircea , Sousa Ana , Ramalho-Santos Joao , Cortesao Paulo , Almeida-Santos Teresa , Ramalhinho Ana , Moura-Ramos Mariana , Melo Miguel , Paiva Isabel

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory infertility. Polymorphisms in genes related to follicular recruitment and development, such as the follicle-stimulating hormone receptor (FSHR) and the oestrogen receptor 1 (ESR1) genes, and their impact on biochemical phenotype and response to controlled ovarian stimulation in women with PCOS have been studied in different populations, with inconsistent results.<p class="abstext...