Searchable abstracts of presentations at key conferences in endocrinology

ea0028p244 | Pituitary | SFEBES2012

Maximising the accuracy of IPSS: Validation of the use of Prolactin as a marker of pituitary venous effluent in the diagnosis of Cushing’s disease

Grant Paul , Carroll Paul

Background: Although early studies with IPSS reported a diagnostic sensitivity and specificity approaching 100%, additional experience has revealed a false negative rate of 1–10%. Previous studies have suggested that the measurement of other anterior pituitary hormones may be useful as a guide to the effectiveness of cannulation and to improve diagnostic accuracy.Method: In this retrospective cohort study, we reviewed all patients who had undergone ...

ea0082p14 | Poster Presentations | SFEEU2022

A functioning pancreatic neuroendocrine tumour presenting as diarrhoea with hypokalaemic acidosis

Rafique Shemitha , Carroll Paul

Case history: 58 year old man presented with collapse secondary to profuse water diarrhoea. He had severe AKI, hypokalaemia, metabolic acidosis, hyponatraemia and hypercalcaemia. He had fluid and electrolyte replacement he in ICU, but profuse diarrhoea persisted and with it, was in hypotension and delerium. He had been having progressive diarrhoea and weight loss for 2 years while he was in South Africa.Investigations: Upper and lower GI endoscopies had ...

ea0048cb1 | Additional Cases | SFEEU2017

Primary hyperparathyroidism in a patient with thyroid hormone resistance

Mohamed Isra Ahmed , Carroll Paul

Introduction: Thyroid hormone resistance due to a TRα mutation is rare and only recently described. We report a case of primary hyperparathyroidism in an adult patient with a known TRα mutation.Case presentation: A 60 year old female was referred with hypercalcaemia and hyperparathyroidism that persisted despite correction of vitamin D deficiency. Parathyroid hormone levels continued to be elevated or inappropriately normal with hyper- or normo...

ea0050p314 | Nursing Practice | SFEBES2017

UK experience with continuous subcutaneous hydrocortisone infusion in patients with adrenal insufficiency

Yeoh Phillip , Khoo Bernard , Carroll Paul

Continouos subcutaneous hydrocortisone infusion (CSHI) is a novo treatment for adrenal insufficieny. This treatment aim to mimic body circadian rhythm by providing a continouos slow infusion subcutanously.We summarise our experience with 5 patients: 1 with primary adrenal insufficiency and 4 with secondary adrenal insufficiency. There are 1 male and 4 females with a mean age 31. All these patients were self referred and have tried ...

ea0050p314 | Nursing Practice | SFEBES2017

UK experience with continuous subcutaneous hydrocortisone infusion in patients with adrenal insufficiency

Yeoh Phillip , Khoo Bernard , Carroll Paul

Continouos subcutaneous hydrocortisone infusion (CSHI) is a novo treatment for adrenal insufficieny. This treatment aim to mimic body circadian rhythm by providing a continouos slow infusion subcutanously.We summarise our experience with 5 patients: 1 with primary adrenal insufficiency and 4 with secondary adrenal insufficiency. There are 1 male and 4 females with a mean age 31. All these patients were self referred and have tried ...

ea0062wc3 | Workshop C: Disorders of the thyroid gland | EU2019

When TFTs just don’t add up

Li Adrian , Saqib Aaisha , Carroll Paul

A 31-year-old man originally from Ukraine attended the clinic having been started on Carbimazole 20 mg by his GP. His symptoms included intermittent palpitations, sweating and poor sleep and they had improved since starting anti-thyroid therapy. He was originally diagnosed with thyrotoxicosis in Germany in 1999 but was not treated and he re-presented in 2005. This time he was started on Carbimazole but stopped treatment on his own accord after a month because his symptoms impr...

ea0062wc9 | Workshop C: Disorders of the thyroid gland | EU2019

When thyroid function tests remain deranged despite treatment

Saqib Aaisha , Li Adrian , Carroll Paul

A 60 year old lady was diagnosed with thyrotoxicosis in 1985 (aged 28) five months postpartum. She underwent partial thyroidectomy in 1990 (age 32). Thyroid tests remained abnormal and in 1992, she underwent radio-iodine treatment requiring post-treatment. She remained under endocrine supervision and the TSH was found to be persistently elevated with normal free thyroid hormone levels (whilst on Levothyroxine). Issue with compliance and assay interference were considered. She ...

ea0025p177 | Endocrine tumours and neoplasia | SFEBES2011

Clinical and biochemical features of sporadic and hereditary phaeochromocytomas and paragangliomas: an analysis of 47 cases investigated in a single centre

Begum Shahina , Carroll Paul , McGowan Barbara

Introduction: Advances in the understanding of the natural history and genetics of phaechromocytomas and paragangliomas have altered the demographics of these conditions resulting in much higher rates of malignancy and association with known genetic abnormalities.Objective: To analyse the clinical and biochemical features of hereditary (H) and sporadic (S) phaeochromocytomas and paragangliomas.Design: Retrospective case-series at G...

ea0077p222 | Neuroendocrinology and Pituitary | SFEBES2021

SDHD missense pathogenic variants: not always benign

Haboosh Sara , Carroll Paul , Izatt Louise , Quinn Mark , Velusamy Anand

Pathogenic variants in the SDHx genes are responsible for ~20% of familial Phaeochromocytoma/Paraganglioma (PPGL) tumours. Metastatic disease is lower in SDHD in comparison to SDHA, B and C mutations. Although the genotype-phenotype relationship is not well established it is considered that truncating SDHD pathogenic variants have a higher risk of causing disease in comparison to missense variants. We present two cases of metastatic paraganglioma in patients with heterozygous ...

ea0055wc2 | Workshop C: Disorders of the thyroid gland (I) | SFEEU2018

Toxic nodule: wait or treat?

Hafeez Saba , Kumar Rakshit , Velusamy Anand , Powrie Jake , Carroll Paul

68 years old female initially referred to endocrine clinic in November 2016 for assessment of fluctuating thyroid function. She had a history of long standing primary hypothyroidism, stable on treatment with 100 mcg Levothyroxine. In last one year, Levothyroxine was tapered and stopped due to persistent suppression of TSH and high normal Free T4. Last tests showed TSH of <0.01mIU/l and Free T4 of 27.1 pmol/l. She had ongoing complaints of feeling increasingly tired and gen...