Searchable abstracts of presentations at key conferences in endocrinology

ea0044oc6.6 | Pregnancy and Reproductive Health | SFEBES2016

Defining the metabolic phenotype of peritoneal mesothelial cells from women with endometriosis

Ahmad Syed F , Carter Roderick N , Collins Frances , Greaves Erin , Morton Nicholas M , Saunders Philippa TK , Horne Andrew W

Endometriosis is a chronic oestrogen-dependent incurable inflammatory disorder, defined by the presence of endometrial-like tissue outside the uterine cavity that affects 6–10% of women of reproductive age. It is associated with debilitating pelvic pain and subfertility with a significant impact on quality of life and estimated annual costs to the UK of £11.7 billion. Recent findings from our laboratory have shown that there is a shift in cell metabolism from mitocho...

ea0065op1.2 | Adrenal and Cardiovascular | SFEBES2019

Glucocorticoids promote mitochondrial fatty acid oxidation in the fetal heart

Urquijo Helena , Panting Emma N , Carter Roderick N , Agnew Emma J , Wyrwoll Caitlin S , Morton Nicholas M , Chapman Karen E , Ivy Jessica R

Background: The late gestational surge in glucocorticoids is vital for the maturation of fetal organs in preparation for birth and survival during the neonatal period. Metabolic maturation of cardiomyocytes involves a switch in fuel substrate from glucose utilization to fatty acid (FA) oxidation. In fetal cardiomyocytes, glucocorticoids induce expression of Ppargc1a (encoding PGC1a, a master regulator of mitochondrial capacity). We hypothesized that glucocorticoids pr...