Searchable abstracts of presentations at key conferences in endocrinology

ea0065oc6.3 | Reproductive Endocrinology and Biology | SFEBES2019

Investigating the impact of altered maternal extracellular vesicle miRNAs on placental function in women with gestational diabetes complicated by large for gestational age infants

Timms Kate , Cartland Sarah J , Ntostis Panagiotis , Saravanan Ponnusamy , Simpson Nigel , Scott Eleanor , Forbes Karen

Gestational diabetes mellitus (GDM) increases fetal morbidity/mortality, and is associated with elevated risks of offspring cardiometabolic disease. These risks are compounded in infants born large for gestational age (LGA) rather than appropriate size (AGA), a common complication of GDM associated with altered placental function. Circulating extracellular vesicle (EV)-associated miRNAs are internalised into the placenta and are emerging as key GDM mediators, with their role i...