Endocrine Abstracts

Phaeochromocytoma in pregnancy is an extremely rare condition. Early recognition can largely decrease maternal and fetal mortality rates. As symptoms of phaeochromocytoma are similar to those of other more common causes of hypertension during pregnancy, timely diagnosis is a challenge. There is no consensus in literature about the specific treatment nor about the optimal delivery timing or route. Case of a 32 years old woman with a single pregnancy of 30 weeks and 3 days admit...

Background: Bilateral adrenal haemorrhage (Waterhouse–Friderichsen syndrome) is a rare consequence of sepsis (usually a result of meningococcal infection), with an estimated 15% mortality. Despite the predominant association with meningococcal infection, there are other recognised aetiologies: sepsis resulting from other organisms, and non-infectious causes, such as anticoagulant treatment, trauma and postoperative adrenal haemorrhage.Case report: A...

Introduction: Seip–Berardinelli congenital lipodystrophy (SBCL) is an extremely rare autosomal recessive disorder characterized by a congenital absence of adipose tissue. Hepatic steatosis, splenomegaly, skeletal muscle hypertrophy, hypertrophic cardiomyopathy, insulin-resistance and diabetes mellitus (DM) are some of the features of these patients.Case report: A 20-year-old caucasian-male patient was referred to pediatric endocrinology unit at 6-mo...

Background: To stratify the risk of malignancy, thyroid fine-needle aspiration cytology (FNAC) is an important and cost-effective method to evaluate nodules. The Bethesda System for Reporting Thyroid Cytopathology III, IV and V categories are diagnostic challenges, falling between benign and malignant.Objective: Determinate the malignancy rates of thyroid nodules classified as Bethesda Categories III-V.Methods: Retrospective study ...

Background: Calcitonin is a hormone secreted by thyroid C cells, and is considered an excellent marker for medullary thyroid carcinoma (MTC). However, the use of calcitonin to screen patients with nodular thyroid disease (NTD) remains controversial.Objective: Defining the frequency of hypercalcitoninemia among NTD patients followed at a tertiary referral hospital.Methods: Retrospective analysis of basal calcitonin measurements and ...

Introduction: Thyroid surgery is nowadays associated with low morbidity and extremely low mortality. A consistent association has been observed between high surgical volume and better outcomes. Patients who undergo surgery by a skilled surgeon have fewer complications. On the other hand, different surgical techniques have been associated with different outcomes. Since 1997, thyroid diseases are treated in our department by a multidisciplinary team.Object...

Introduction: Fine needle aspiration biopsy (FNAB) plays an essential role in the evaluation of thyroid nodular disease (TND). It reduces the rate of unnecessary thyroid surgery for patients with benign nodules, and allows the choice of the appropriate surgery. In our department, 2124 FNAB were performed in 10 years. 60% of them are now ultrasound guided (UGFNAB).Objective: To access the accuracy of FNAB in our hospital.Methods: Re...

Introduction: The use of Continuous Subcutaneous Insulin Infusion (CSII) is expected to improve glycemic control and to reduce hypoglycemia events. However, long-term beneficial results in glucose control are not always observed. We evaluated long-time glucose control and severe hypoglycemias in type 1 diabetic patients using CSII, without continuous glucose monitoring.Patients and methods: This was a retrospective study of adult type 1 diabetic patients...

Introduction: Maturity onset diabetes of the young (MODY) accounts for 1-2% of all forms of diabetes mellitus (DM). As classic criteria that lead to its suspicion have low sensitivity, patients are often misdiagnosed with type 1 or type 2 DM. Correct classification of this type of diabetes becomes essential for proper management of the disease. Our objective was to describe clinical features of patients with MODY diagnosed at our institution.Methods: We ...