Searchable abstracts of presentations at key conferences in endocrinology

ea0032p23 | Adrenal cortex | ECE2013

Immunohistochemical markers of adrenal cortical tumors

Altieri Barbara , Fadda Guido , Capozzi Anna , Pontecorvi Alfredo , Casa Silvia Della

Introduction: Adrenocortical tumors (ACTs) are usually divided in adenoma (ACA) or carcinoma (ACC) according to histopathologic methods. Some lesions are occasionally difficult to classify according to these criteria. We studied the use of some immunohistochemical markers to recognise the difference between malignant and benign tumors.Materials and methods: We studied 12 patients affected by ACC and 10 by ACA. Clinical evaluation and hormone analysis wer...

ea0020p19 | Adrenal | ECE2009

Adipokine levels in patients with adrenal incidentaloma

Iorio Laura , Morelli Valentina , Coletti Francesca , Della Casa Sonia , Arosio Maura , Corsi Massimiliano , Chiodini Iacopo , Ambrosi Bruno

Patients (pts) with adrenal incidentaloma (AI) may show an increased incidence of several cardiovascular risk factors, as obesity, hypertension, diabetes mellitus and dyslipidemia. As previous data suggested that the increased cardiovascular risk in these pts could be in part mediated by alterations of adipokines, this study was aimed to evaluate plasma IL-6, resistin, CT-1 levels in a wide series of pts with AI.Ninety-three pts (42 males; 51 females; ag...

ea0014p198 | (1) | ECE2007

Evaluation of visceral protein malnutrition in morbid obese patients operated on laparoscopic gastric bypass

Casañ Rosa , Morillas Carlos , Sola Eva , García Katherinne , Yanini Jesus , Jover Ana , Gomez Marcelino , Hernández Antonio

Morbid obesity is associated with a decreased life expectancy and a myriad of serious medical problems. The Roux-en-Y gastric bypass (RYGBP) is the most effective procedure for the treatment of these patients, but it can be responsible of early and late complications. The aim of this prospective study was to evaluate the rate of visceral protein malnutrition (VPM) in morbid obese (MO) patients two years after laparoscopic RYGBP. Albumin (Alb), prealbumin (Prealb), transferrin ...

ea0067o14 | Oral Presentations | EYES2019

Effects of thyroid function on peripheral serum markers: results from a cohort of thyroid cancer patients

Monzani Maria Laura , De Vincentis Sara , Della Casa Venturelli Francesca , Piccinini Francesca , Tagliavini Simonetta , Peeters Robin P , Simoni Manuela , Brigante Giulia

Objective: The aim of this study was to identify changes in thyroid hormone metabolism occurring in different thyroid functional states and to evaluate tissue response to thyroid hormone changes.Methods: Two hundred subjects (137 F, 63 M, mean age: 50.3±14.4 years) waiting to be treated or treated with total thyroidectomy for differentiated thyroid cancer were enrolled in this study. Thyroid function was investigated measuring TSH, fT4 and fT3, and ...

ea0063p1205 | Thyroid 3 | ECE2019

Quality of life in patients thyroidectomized for differentiated thyroid cancer

Laura Monzani Maria , De Vincentis Sara , Della Casa Venturelli Francesca , Piccinini Francesca , Tagliavini Simonetta , Peeters Robin P. , Simoni Manuela , Brigante Giulia

Background: The evaluation of health-related Quality of Life (QoL) is becoming a key component in clinical assessment of thyreopathic patients, especially those thyroidectomized for differentiated thyroid cancer (DTC) and treated with levothyroxine (LT4).Aim: To evaluate QoL in different thyroid states in patients treated with total thyroidectomy for DTC and correlate it with thyroid function tests.Methods: Two hundred subjects (13...

ea0049ep161 | Endocrine tumours and neoplasia | ECE2017

CYP2W1*6 polymorphism as a potential predictive marker of sensitivity to mitotane treatment in adrenocortical carcinoma.

Altieri Barbara , Herterich Sabine , Sbiera Silviu , Volante Marco , Kroiss Matthias , Casa Silvia Della , Pontecorvi Alfredo , Terzolo Massimo , Fassnacht Martin , Ronchi Cristina L.

Mitotane is the only approved drug for the treatment of advanced adrenocortical carcinoma (ACC) and we recently demonstrated that a high expression of cytochrome P450 2W1 (CYP2W1) correlated with response to mitotane. The association between CYP2W1 alleles and a generally increased cancer risk is under debate. Aim of the study was to evaluate the frequency of CYP2W1 polymorphisms and its correlation with the response to mitotane treatment in ACC patients.<p class="abstext"...

ea0037ep1131 | Endocrine tumours | ECE2015

Inhibitor of apoptosis protein livin/BIRC7 in adrenocortical tumours

Altieri Barbara , Sbiera Silviu , Casa Silvia Della , Steinhauer Sonja , Wild Vanessa , Fadda Guido , Bekteshi Michaela , Rosenwald Andreas , Pontecorvi Alfredo , Fassnacht Martin , Allolio Bruno , Ronchi Cristina L

Introduction: Adrenocortical tumours comprise frequent adenomas (ACA) and rare highly malignant carcinoma (ACC). Livin/ML-IAP/BIRC7 is a member of the inhibitors of apoptosis proteins family, which are involved in tumorigenesis, mostly through the inhibition of caspase-3. Aim of the study was to evaluate the expression of livin/BIRC7 in normal and neoplastic adrenal glands.Methods: The mRNA expression of BIRC7, its isoforms livin α...

ea0035p655 | Female reproduction | ECE2014

Dietetic Therapy aimed to restart menstrual period in patients affected by anorexia nervosa in weight recovery

Policola Caterina , Musca Tania , Cefalo Chiara Maria Assunta , Siciliano Ludovico Luca , Lassandro Anna Pia , Meniconi Paola , Miggiano Giacinto Abele Donato , Casa Silvia Della

Anorexia Nervosa (AN) is a severe eating disorder characterized by significantly low body weight and fear of gaining weight. Amenorrhea is a very frequent feature in AN and it could persist after normalization of BMI. A well-represented fat mass and an adequate body composition (BC) are necessary for resumption of periods. Patients affected by AN, although in the remission phase, fear of becoming fat and refuse to gain weight. In our study we evaluated the effect of a normocal...

ea0011p904 | Thyroid | ECE2006

Modifications in the frequency of presentation and the TNM stage at diagnosis of thyroid carcinoma in the last decade in Valencia (Spain)

Yanini J , Casañ R , García K , Jover A , Gómez M , Solá E , Morillas C , Peña H , Muñoz ML , Hernández A

Aims: The aim of the present study was to evaluate the relative frequency of histological categories of thyroid malignant neoplasms. Another aim was to evaluate the TNM stage differentiated thyroid carcinoma (DTC) at the time of initial presentation in Valencia Community (Spain).Methods: Histopathology and TNM stage thyroid carcinomas diagnosed of thyroid carcinoma diagnosed between 1998 and 2005 in our endocrinology service, were recorded.The sample was...

ea0063p25 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Management of mitotane for advanced adrenocortical carcinoma: a survey in Italy

Puglisi Soraya , Saba Laura , Perotti Paola , Calabrese Anna , Basile Vittoria , Arnaldi Giorgio , Cannavo Salvatore , Stigliano Antonio , Canu Letizia , Loli Paola , Pivonello Rosario , Malandrino Pasqualino , Badalamenti Giuseppe , Torlontano Massimo , Della Casa Silvia , Scaroni Carla , Terzolo Massimo

Background and objective: Mitotane is the main option of treatment for advanced adrenocortical carcinoma (ACC). However, limited evidence is available regarding practical management of mitotane treatment and its eventual combination with chemotherapy or radiotherapy. The aim of the study is to do a survey on the use of mitotane for advanced ACC in expert Italian centers, analyzing data of the LYSOSAFE database.Methods: Retrospective analysis of patients ...