Searchable abstracts of presentations at key conferences in endocrinology

ea0011s2 | Geoffrey Harris Prize Lecture | ECE2006

A tale of modern endocrinology

Casanueva Felipe

Growth hormone (GH) is regulated by two antagonistic hypothalamic hormones, GHRH and somatostatin, plus the liver-derived hormone IGF-I and metabolic signals. Then GH actions are implicated on somatic growth and in the regulation of general metabolism.Developed in the seventies of past century, GH secretagogues (GHS) are small artificial molecules, either peptidyl or non-peptidyl, who actively discharge GH in all animal species so far studied and through...

ea0020me9 | (1) | ECE2009

New drugs in the management of the obese patients

Casanueva Felipe F

In the prevalence of obesity has increased worldwide reaching 30% of the adult population in some countries. Direct and inferential evidences show that this excess of body fat is associated with adverse health consequences, and that even a modest 5 to 10% weight loss results in substantial improvement in health. Considering the limited efficacy of the so-called ‘life style’ interventions based on diet plus exercise in the obese subjects, and that bariatric surgery is...

ea0063p731 | Pituitary and Neuroendocrinology 2 | ECE2019

Therapeutic decisions in acromegaly according to disease control in patients with acromegaly with or without prior treatment: data from baseline analysis of the SAGIT® validation study

Giustina Andrea , Bronstein Marcello , Chanson Philippe , Petersenn Stephan , Casanueva Felipe , Sert Caroline , Houchard Aude , Melmed Shlomo

Background: The SAGIT® instrument, designed to assist clinicians in staging and managing acromegaly, is undergoing validation. A descriptive analysis of SAGIT Validation study baseline data revealed discrepancies between investigator-evaluated disease-control status, disease activity, hormonal control, and treatment decisions in acromegaly.Objective: To describe the baseline characteristics of patients in the SAGIT® valida...

ea0035p731 | Neuroendocrinology | ECE2014

Influence of the exon 3 deletion of GH receptor and IGF1 level at diagnosis on the efficacy and safety of treatment with somatotropin in adults with GH deficiency

Andujar-Plata Paula , Fernandez-Rodriguez Eva , Quinteiro Celsa , Casanueva Felipe , Bernabeu Ignacio

Introduction: Human recombinant growth hormone (hrGH) treatment in adult patients with GH deficiency (GHD) has an important interindividual variability and several factors can influence it. The aims of the study were: i)- to analyze the genotype of GHR regarding exon 3 deletion (d3-GHR) in a serie of adult patients with GHD; ii)- to assess the effect of d3-GHR on initial IGF1 levels; iii)- to evaluate if d3-GHR and/or initial IGF1 levels were associated with adverse effects an...

ea0020p553 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Ghrelin as new provocative test for the diagnosis of GH deficiency in adults

Gasco Valentina , Rovere Silvia , Beccuti Guglielmo , Broglio Fabio , Aimaretti Gianluca , Grottoli Silvia , Casanueva Felipe , Ghigo Ezio

ITT is the test of reference for the diagnosis of adult GH deficiency (GHD), but it is recognized that also GHRH in combination with arginine (ARG) or GH secretagogues (GHS) are equally reliable tests. It has also been suggested that testing with GHS would represent a potent stimulus exploring also the integrity of hypothalamic pathways controlling somatotropic function. We therefore aimed to clarify the diagnostic reliability of testing with ghrelin, the natural GHS. We studi...

ea0016p69 | Bone and calcium | ECE2008

Bone metabolism in hypothalamic obesity

Doknic Mirjana , Pekic Sandra , Miljic Dragana , Stojanovic Marko , Djurovic Marina , Dieguez Carlos , Casanueva Felipe , Popovic Vera

Obesity protects from osteoporosis. Bone remodeling and energy metabolism could be regulated by the adipocyte-derived hormone, leptin acting on osteoblasts though hypothalamic pathways. Hypothalamic lesions cause obesity. Since most of these patients are also hypopituitary with low IGF1 which could affect bone metabolism the aim of our study was to investigate whether obesity would protect them from osteoporosis.Three groups of patients were studied: (1)...

ea0016p386 | Neuroendocrinology | ECE2008

Isolated GH deficiency of adult-onset in the KIMS database: prevalence, clinical presentation, and response to GH replacement

Casanueva Felipe , Abs Roger , Popovic Vera , Koltowska-Haggstrom Maria , Jonsson Bjorn , Saller Bernhard , Kourides Ione

Of the ~12 500 GH treated subjects with adult-onset GH deficiency (GHD) in KIMS (Pfizer International Metabolic Database), 3744 with multiple pituitary hormone deficiencies (MPHD) and 367 (9%) with isolated GHD (iGHD) were eligible for baseline analysis. Subjects met the following inclusion criteria: 1) never received GH prior to entry in KIMS, 2) had stimulation tests with insulin or glucagon (GH<3 μg/l), arginine (GH<0.4 μg/l), or arginine+GHRH (cut-offs ba...

ea0016p432 | Neuroendocrinology | ECE2008

GHRH as a possible allosteric ligand of the ghrelin receptor GHS-R1a

Carreira Marcos C , Camina Jesus P , Lage Mary , Casanueva Felipe F

Ghrelin and GHRH are two hormones involved in the growth hormone (GH) secretion through their respective receptors. The growth hormone secretagogue receptor subtype 1a (GHS-R1a) is involved in biological actions exerted by ghrelin triggering intracellular second messengers coupled to Gαq/11 protein. In this work, we analyzed the possible interaction between GHRH and GHS-R1a as well as the subsequent intracellular pathways. The results showed that GHRH induced, ...

ea0016p481 | Neuroendocrinology | ECE2008

Hypopituitarism after traumatic brain injury and its possible relation with neurocognitive and psychiatric disturbances

Castro Ana I , Lage Mary , Peino Roberto , Lorenzo Monica , Casanueva Felipe

Introduction: Recent advances in medicine have allowed a considerably decrease in mortality after traumatic brain injury (TBI) with the consequent increment in the number of subjects with physical, psychological and cognitive sequelas which means an important worsening of quality of life as well as difficulties in social and labour integration. Considering that many of the symptoms classically attributed to the TBI (memory impairment, concentration impairment, fatigue, social ...

ea0016p535 | Obesity | ECE2008

Postnatal determination of ghrelin secretion levels and sexual dimorfism in the rat

Al-Massadi Omar , Gonzalez Carmen Ruth , Pardo Maria , Dieguez Carlos , Casanueva Felipe , Seoane Luisa Maria

Ghrelin is a pleiotropic hormone characterized mainly by its strong orexigenic action and its role as GH secretagogue.Age-related level variation of this hormone has been previously shown in different studies centred in mARN expression and in its plasma levels; however there is no data about its secretion directly from the stomach although this is the main ghrelin producing organ.Objectives: To determine the levels of ghrelin in th...