Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep164 | Calcium and Bone | ECE2022

The clinical presentation of primary hyperparathyroidism during the Covid-19 pandemic

Castellano Elena , Borretta Giorgio , Pellegrino Micaela , Tassone Francesco , Craparo Andrea , Baffoni Claudia , Gianotti Laura

Background: In the last decades, the clinical profile of PHPT in Western Countries has changed from a highly symptomatic to a largely asymptomatic disease. However, a substantial stability in its clinical features has been reported in the last two decades. The usual management, including time to diagnosis and treatment, of PHPT during the Covid-19 pandemic has been changed and likely slowed down. Whether further changes in the clinical presentation of PHPT have occurred during...

ea0049ep268 | Calcium & Vitamin D metabolism | ECE2017

Gender difference in clinical presentation of primary hyperparathyroidism

Gianotti Laura , Castellano Elena , Tassone Francesco , Baffoni Claudia , Cesario Flora , Magro Gianpaolo , Pellegrino Micaela , Borretta Giorgio

Objective: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders, with a female to male ratio of 3:1. Currently most patients with PHPT are asymptomatic. However, data about the gender impact on the clinical presentation of PHPT are lacking.Methods: We evaluated the difference in symptoms and biochemical parameters between men and women with PHPT in a single center series of 417 patients.Results: Male PHP...

ea0037ep264 | Calcium and Vitamin D metabolism | ECE2015

Measuring BMD at forearm aids in diagnosing osteoporosis and identifies more patients for surgery in asymptomatic primary hyperparathyroidism

Gianotti Laura , Castellano Elena , Tassone Francesco , Pellegrino Micaela , Ghio Michela , Racca Anna , Borretta Giorgio

Introduction: Reduction in bone mineral density (BMD) is a common feature in primary hyperparathyroidism (PHPT), involving mostly cortical site. In the management of asymptomatic PHPT (aPHPT), guidelines indicate measuring BMD at lumbar spine, hip and forearm and surgery is recommended for patients with a T-score of −2.5 or less at one of these sites. However, BMD at forearm is not always performed.Aim: Our aim was to evaluate the impact o...

ea0056p1032 | Thyroid (non-cancer) | ECE2018

Thyroid disease in PHPT: a single centre study

Castellano Elena , Gianotti Laura , Latina Adele , Cesario Flora , Baffoni Claudia , Pellegrino Micaela , Tassone Francesco , Magro Giampaolo , Borretta Giorgio

Objective: Primary hyperparathyroidism (PHPT) and thyroid diseases are common in the general population. It is difficult to establish whether they occur in the same patient because of a direct relationship or just due to the widespread prevalence of both conditions. The reported prevalence of the concomitant occurrence of these two clinical conditions is widely scattered (ranging 17–84%), especially due to the heterogeneous criteria for patient selection. We aimed to eval...

ea0090oc8.6 | Oral Communications 8: Calcium and Bone | ECE2023

Skeletal phenotypes in postmenopausal women with primary hyperparathyroidism (PHPT)

Corbetta Sabrina , Gianotti Laura , Castellano Elena , Raineri Francesca , Munari Elisabetta , Guabello Gregorio , Pierotti Laura , Dinoi Elisa , Valentina Simone Della , Cetani Filomena

Current clinical presentation of PHPT is mild disease with an increased risk of fragility fractures. PHPT predominantly occurs in postmenopausal women, who have an increased risk of osteoporosis and fractures due to ageing and loss of estrogen.Aims: To explore skeletal phenotypes in postmenopausal women affected by PHPT with a wide clinical and biochemical spectrum of disease.Patients: Postmenopausal (at least 5 years from last men...

ea0070aep206 | Bone and Calcium | ECE2020

Parathyroid carcinoma: An italian multicenter retrospective analysis

Gianotti Laura , Castellano Elena , Lauro Corrado , Piovesan Alessandro , Procopio Massimo , Barale Marco , Palestini Nicola , Quaglino Francesco , Manfrino Luca , Bullara Valentina , Volante Marco , Borretta Giorgio

Parathyroid carcinoma (PC) is a rare neoplasia responsible for about 1% of primary hyperparathyroidism (PHPT). Differently from patients with its benign counterpart, the phenotype of these patients is characterized by severe PHPT and hypercalcemia. The aim of this study was to describe a series of PC casesrecorded in the regional cancer network of Piedmont and Valle d’Aosta, Italy (Rete Oncologica del Piemonte e della Valle d’Aosta) from 2007 to 2017, including 25 ...

ea0070aep787 | Reproductive and Developmental Endocrinology | ECE2020

Clinical and genetic characterization of two cases of central hypogonadism in Klinefelter syndrome

Indirli Rita , Cangiano Biagio , Profka Eriselda , Castellano Elena , Goggi Giovanni , Mantovani Giovanna , Arosio Maura , Persani Luca , Borretta Giorgio , Ferrante Emanuele , Bonomi Marco

Introduction: Klinefelter syndrome (KS) is generally characterized by late adolescence/young adulthood onset of primary hypergonadotropic hypogonadism. Fourteen cases have been previously reported on apparently unexplained isolated hypogonadotropic hypogonadism (IHH) in KS. Gonadotropins defect was variably associated with anosmia or other pituitary hormones deficiencies, but no cause could be clearly identified to explain the central defect. We describe the clinical and genet...

ea0049gp33 | Bone & Calcium Homeostasis 1 | ECE2017

“Hyperparanet”: a multicenter Italian study on Primary Hyperparathyroidism

Saponaro Federica , Cetani Filomena , Camozzi Valentina , D'Angelo Antonella , Minisola Salvatore , Scillitani Alfredo , Cipri Claudia , Palmieri Serena , Chiodini Iacopo , Romanelli Francesco , Madeo Bruno , Castellano Elena , Gianotti Laura , Faggiano Antongiulio , Cianferotti Luisella , Brandi Maria Luisa , Corbetta Sabrina , De Feo Maria Laura , Palermo Andrea , Marcocci Claudio

The aim of the present study was to evaluate the phenotype of PHPT, the adherence to International Guidelines and the rate of surgical cure of PHPT in Italy. From January 2014–January 2016, we conducted a prospective, multicenter (n=29 endocrine tertiary referral centers) study on patients with PHPT, recording clinical and biochemical data, parathyroid imaging and therapy choice at baseline and at last follow-up. The study group included 604 patients with PHPT, w...