Searchable abstracts of presentations at key conferences in endocrinology

ea0022p592 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

The anorexigenic neuropeptide, NUCB2/nesfatin-1, is indispensable for normal puberty onset in the female rat

Garcia-Galiano David , Navarro Victor M , Roa Juan , Ruiz-Pino Francisco , Castellano Juan M , Dieguez Carlos , Pinilla Leonor , Tena-Sempere Manuel

The hypothalamic peptide, nesfatin-1, derived from the precursor NEFA/nucleobindin2 (NUCB2), was recently identified as central anorexigenic molecule, acting in a leptin-independent manner. Yet, its potential involvement in the regulation of other biological functions gated by body energy status remains unexplored. We show herein that NUCB2/nesfatin-1 is involved in the control of female puberty. NUCB2/nesfatin mRNA and protein were detected at the hypothalamus of pubertal fem...

ea0037gp.13.04 | Diabetes and obesity – Translational cardiovascular and obesity | ECE2015

Metabolic and gonadotropic impact of sequential obesogenic insults in the female: influence of the loss of ovarian secretion

Sanchez-Garrido Miguel A , Ruiz-Pino Francisco , Manfredi-Lozano Maria , Leon Silvia , Heras Violeta , Castellano Juan M , Vazquez Maria Jesus , Roa Juan , Romero-Ruiz Antonio , Dieguez Carlos , Pinilla Leonor , Tena-Sempere Manuel

While female fertility is known to be sensitive to conditions of low body fuel reserves, the reproductive consequences of persistent energy excess remain ill defined. Yet, the pandemic proportions of obesity, and its potential impact on the gonadotropic axis, call for a better understanding of this phenomenon. Alike, the influence of ovarian hormones on the pathophysiology of obesity and its complications merits further investigation. In this work, we aimed to elucidate the me...

ea0063gp62 | Reproductive Axis | ECE2019

Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3

Castellano Juan M , Heras Violeta , Sangiao-Alvarellos Susana , Manfredi-Lozano Maria , Sanchez-Tapia Maria J , Ruiz-Pino Francisco , Roa Juan , Lara-Chica Maribel , Morrugares-Carmona Rosario , Abreu Ana P , Belsham Denise , Vazquez Maria J , Calzado Marco A , Pinilla Leonor , Gaytan Francisco , Latronico Ana C , Kaiser Ursula B , Tena-Sempere Manuel

Mkrn3, the maternally imprinted gene encoding the makorin RING-finger protein-3, has recently emerged as putative pubertal repressor, as evidenced by central precocity caused by MKRN3 mutations in humans; yet, the molecular underpinnings of this key regulatory action remain largely unexplored. We report herein that the microRNA, miR-30, with three binding sites in a highly conserved region of its 3’-untranslated region (UTR), operates as repressor of Mkrn3 to control pube...