ea0008oc23 | Young Endocrinologist Session | SFE2004
Dhillo WS
, Castle L
, Gardiner JV
, Bewick GA
, Smith KL
, Meeran K
, Todd JF
, Ghatei MA
, Bloom SR
Alpha melanocyte stimulating hormone (alpha-MSH) is an agonist at the melanocortin 3 receptor (MC3-R) and MC4-R and stimulates corticosterone release from rat and human adrenal cells. Patients with Cushing's syndrome have elevated levels of serum alpha-MSH. Agouti related protein (AgRP) is an endogenous antagonist at the MC3-R and MC4-R and is expressed in the rat adrenal cortex. AgRP antagonises alpha-MSH-induced corticosterone release from rat and bovine adrenal cells. This ...