Searchable abstracts of presentations at key conferences in endocrinology

ea0031p42 | Clinical biochemistry | SFEBES2013

Glycosylated linkers to generate long-acting GH tandems

Wilkinson Ian , Cawley Pippa , Bielohuby Maximilian , Sayers Jon , Artymiuk Peter , Bidlingmaier Martin , Ross Richard

Background: The development of recombinant biologics has had a major impact on many diseases. However, most biologics are rapidly cleared from the body and therefore require frequent injection regimens. There is therefore a need for technologies that allow the half-lives of these molecules to be extended in a predictable manner.HypothesisIncreasing numbers of N-linked glycosylation motifs between two GH molecules leads to gradually...