ea0011p823 | Thyroid | ECE2006
Di Cosmo C
, Tonacchera M
, De Marco G
, Agretti P
, Banco ME
, Perri A
, Ramos H
, Ceccarelli C
, Vitti P
, Pinchera A
Congenital hypothyroidism (CH) with a normal located thyroid gland may be transient or permanent and environmental, iatrogenic, immunologic or genetic factors can be involved. PAX-8, TSH receptor and THOX2 gene mutations have been identified in cases of CH with a gland of normal size.In this study we performed genetic analysis of PAX8, TSH receptor and THOX2 genes in 14 children with CH and a normal sized eutopic gland. Genomic DNA was extracted from lym...