Searchable abstracts of presentations at key conferences in endocrinology

ea0089t1 | Trials In Progress | NANETS2022

Phase Ia/Ib Study of BAY1895344 Plus Topoisomerase I Inhibitors with a Focus on Poorly Differentiated Neuroendocrine Carcinomas and Pancreatic Adenocarcinoma

Stockton Shannon , Dan Ayers G. , Cecchini Michael , Ajumaily Raid , Whisenant Jennifer , Gore Steven , Ivy Percy , LoRusso Patricia , Berlin Jordan , Das Satya

Background: Advanced small cell lung cancer (SCLC), extra-pulmonary neuroendocrine carcinoma (EP-NEC) and pancreatic adenocarcinoma (PDA) are rapidly progressive cancers characterized by unbridled replication stress. Patients with these malignancies possess dismal prognoses with limited options after initial first-line chemotherapy. These tumors rely on the integrity of DNA damage repair pathways to ensure genomic stability. The ataxia telangiectasia and Rad3-related (ATR) pro...