Searchable abstracts of presentations at key conferences in endocrinology

ea0022p423 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Reversible heart failure after sorafenib administration in advanced metastatic differentiated thyroid carcinoma (DTC)

Giusti Massimo , Derchi Maria , Mortara Lorenzo , Canepa Mario , Cecoli Francesca , Minuto Francesco , Spallarossa Paolo

Sorafenib (S) is a reasonably well-tolerated therapy in DTC. A large number of side-effects have been reported. We report our data on the effectiveness and tolerability of S in 6 patients with advanced metastatic epithelial (2 follicular, 1 papillary, 1 insular) and medullary DTCs (52–79 years). In all patients, heart function was evaluated before and during S administration (400 mg/day) together with the objective response rate and changes in serum markers. Underlying he...

ea0020p70 | Thyroid | ECE2009

Recombinant-human TSH (rhTSH) testing in patients with history of thyroid microcarcinomas

Capitanio Selene , Cecoli Francesca , Mortara Lorenzo , Fiz Francesco , Caorsi Valeria , Minuto Francesco , Giusti Massimo

Papillary thyroid microcarcinoma (mPTC) is being diagnosed increasingly frequently. Multifocality and nodal involvement are sometimes reported on diagnosis. Management ranges from observation to total thyroidectomy (Tx) followed by radioiodine (RAI) ablation. The role of rhTSH testing in mPTC has not been fully investigated. Torlontano et al. (2006) recently observed that rhTSH-stimulated Tg levels mainly depend on normal tissue remnant. Aim of this study was to further...

ea0014p215 | (1) | ECE2007

Absence of TSH-induced increase in leptin levels in patients with history of differentiated thyroid carcinoma undergoing rhTSH testing

Cecoli Francesca , Andraghetti Gabriella , Ghiara Carla , Briatore Lucia , Cavallero Domenico , Mussap Michele , Minuto Francesco , Giusti Massimo

Some extra-thyroid effects of TSH have been described in vitro and in vivo. TSH has recently been suggested to induce IL-6 secretion from adipocytes. Leptin is the main secretory protein from adipose tissue. Our aim was to evaluate the acute effect of rhTSH-induced TSH surge on serum leptin levels in differentiated thyroid carcinoma (DTC) patients. Ten patients (2 m, 8 f; age range 31–66 years) with stage 1-3 DTC were evaluated during scheduled standard rhTS...