Endocrine Abstracts

Introduction: The use of iodinated contrast media (ICM) can lead to thyrotoxicosis, especially in patients with risk factors, such as Graves’ disease, multinodular goiter, older age, and iodine deficiency. Although hyperthyroidism may have clinically relevant effects, whether high-risk patients should receive prophylactic treatment before they are administered ICM is still debated.Aim of the study: We aimed to demonstrate the safety and efficacy of ...

Background: Pheochromocytoma (Pheo) is a tumor deriving from chromaffin cells. It can be studied using 18F-dihydroxyphenylalanine (DOPA) - positron emission tomography (PET) due to its overexpression of L-type amino acid transporters (LAT1 and LAT2). The oncogenic pathways involved are still poorly understood. This study examined the relationship between 18F-DOPA-PET uptake and LAT1 expression, and explored the role of miR-375 and putative target genes.</...

Papillary thyroid cancer (PTC) is the 8th most common cancer among women overall. Licorice (Li) contains over 300 active compounds and many of them with anti-cancer properties. Glycyrrhetinic acid (GA) is a major component of Li and a mineralocorticoid receptor agonist. The aim of this study was to investigate the potential anti-proliferative effects of Li and GA on PTC cell cultures. Li extract (LE) was produced from the root and tested on BCPAP and K1 cell lines, as well as ...

Objective: No consensus has been reached yet on whether iodine supplementation should be recommended also in pregnant women with Hashimoto’s thyroiditis who are receiving levothyroxine (LT4) therapy. We aimed to evaluating the iodine status in a sample of pregnant women residing in the Veneto region of Italy and suffering from autoimmune thyroiditis. Here we present our preliminary results.Methods: 81 pregnant women with Hashimoto’s thyroiditis...

Background: Hobnail variant of papillary thyroid carcinoma (HPTC) has been recently identified. Given the rarity of the variant its characteristics have been studied only in little series, limiting the quality of the data available for its better management. The aims of our retrospective study were 1) to define the clinical and molecular characteristics of a series of HPTC in a monocentric and relatively large series; 2) to define the clinical and molecular characteristics abl...

A 52-year man came to Emergency Department with Atrial Fibrillation with rapid ventricular response due to amiodarone induced thyrotoxicosis (AIT). The patient was found tachi-arrhythmic (153 beats per minute), tachypnoic (27 breaths per minute) and with intense hyperidrosis. His first blood test documented thyroid stimulating hormone (TSH) <0.01 mUI/l, free triiodothyronine (fT3) 20.0 pmol/l and free thyroxine (fT4) over 100 pmol/l. Thyroid ultrasonography revealed an enl...

Introduction: Thyroid eye disease (TED) is an immune-mediated disorder of the eye. Intravenous glucocorticoid (GC) is the first-line treatment for active moderate to severe TED patients. However, the rate of response is between 50 and 80%. Reliable and easily accessible markers of responsiveness to GC therapy are still lacking.Aim of the study: We aimed to explore the possible role of miR-146a and miR-21 as a predictor of responsiveness to GC treatment i...

Objectives: An improvement in iodine status in Veneto region has been documented in the last decade. We aimed at estimating the incidence of autoimmune hypotiroidism (AH) in the Veneto Region over the period 2013-2022.Methods: Retrospective population-based study conducted in Veneto (4.9 million people) using the population registry, an administrative health database. Between 2012 and 2022, AH incidence was defined thank to a health-care co-payment exemp...

Objectives: The aim was to evaluate the iodine nutritional status in pregnant women residing in Veneto region and its associations with diet, iodine supplements and social status (nationality and education).Methods: 292 consecutive pregnant women at the third trimester of pregnancy were enrolled (≥18 years old, and resident in Veneto). Exclusion criteria were a personal history of thyroid disease and the refusal of the informed consent. Every woman...

Background: Calcitonin (CT) is the most sensitive marker for MTC diagnosis. By the way, many pre-analytical, analytical and post-analytical pitfalls worsen its accuracy. Procalcitonin (proCT), a CT precursor, has been suggested as a valuable complementary test in MTC diagnosis, given its stability and the reproducibility between different assay kits.Material and Methods: basal CT (bCT) and proCT (bproCT) and stimulated CT (bCT) and proCT (sproCT) (2&#821...