Searchable abstracts of presentations at key conferences in endocrinology

ea0016p353 | Growth and development | ECE2008

Impaired Se metabolism provokes gender-specific growth defects in mice

Renko Kostja , Chadt Alexandra , Michaelis Marten , Schweizer Ulrich , Al-Hasani Hadi , Kohrle Josef , Schomburg Lutz

Background: Selenoproteins are involved in oxidative stress defence, cell signalling and hormone metabolism. Accordingly, impairment of selenium (Se) metabolism or transport results in a complex phenotype as exemplified in selenoprotein P knockout mice (SePP-KO). This mouse model is characterized by a disrupted metabolism of Se resulting in neurological and growth defects. Hypothesis: Se impairs regular tissue development by modifying growth signal biosynthesis, anabolic respo...