Searchable abstracts of presentations at key conferences in endocrinology

ea0028p317 | Steroids | SFEBES2012

Effects of mitotane on exogenous and endogenous steroid metabolism

Ghataore Lea , Chakraborti Indira , Aylwin Simon , Schulte Klaus-Martin , Taylor Norman

Objective: Mitotane (o,p’DDD) is an effective adrenolytic agent for treatment of advanced adrenocortical carcinoma (ACC). Suppression of cortisol biosynthesis, including inhibition of 11β-hydroxylation, has been described. Decreased cortisol bioavailability is indicated by increased dose requirement for hydrocortisone replacement during mitotane treatment. Urinary excretion of common cortisol metabolites (CM) has been reported to be normal but with increase of 6&#946...