Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep299 | Calcium & Vitamin D metabolism | ECE2017

Serum vitamin D in overweight patients with normal and impaired GFR

Tigas Stelios , Kitsos Athanasios , Dounousi Evangelia , Kalaitzidis Rigas , Challa Anna , Siamopoulos Costas

Introduction: Obesity is a strong risk factor for incident chronic kidney disease (CKD). Furthermore, high body mass index (BMI) is consistently associated with low serum vitamin D in the general population. The aims of the present study were to i) compare vitamin D metabolite levels in overweight/obese versus normal weight individuals with normal to severely impaired renal function and ii) to assess the impact of 25(OH)D on the development of secondary hyperparathyroidism (SH...

ea0026p524 | Bone/calcium/Vitamin D | ECE2011

Association of the A1330V and V667M polymorphisms of LRP5 with bone mineral density in Greek peri- and postmenopausal women

Markatseli A , Hatzi E , Bouba I , Georgiou I , Challa A , Tigas S , Tsatsoulis A

Wnt signaling through low-density lipoprotein receptor-related protein 5 (LRP5) is an important determinant of bone mass regulation. Polymorphisms in the LRP5 gene have been associated with either osteoporotic phenotypes or normal bone mineral density (BMD) variation.Objective: To explore the influence of two LRP5 single nucleotide polymorphisms (SNPs) A1330V and V667M on BMD and serum levels of osteoprotegerin (OPG), receptor activator of nuclear factor...