Searchable abstracts of presentations at key conferences in endocrinology

ea0044p190 | Obesity and Metabolism | SFEBES2016

Maternal high fat diet exposure and offspring metabolism: a meta-regression analysis of animal models

Ribaroff George , Wastnedge Elizabeth , Drake Amanda , Sharpe Richard , Chambers Thomas

Background: Maternal high fat diet (HFD) exposure is thought to perturb offspring metabolism, however the literature on experimental animal studies is inconsistent.Objectives: (i) In experimental studies, appraise data regarding metabolic parameters in offspring of mothers who consumed a HFD, (ii) assess possible predictors for these, and (iii) explore the quality of the evidence base.Methods: Searches were performed in four electr...

ea0059p036 | Adrenal and steroids | SFEBES2018

Modelling glucocorticoid-induced HPA axis suppression in mice

Nolan Oscar , Romano Nicola , Le Tissier Paul , Shipston Mike , Chambers Thomas

Background: Glucocorticoids are prescribed for >3 months to 1% of the UK population, principally to control inflammation. In 10–30% of patients, chronic glucocorticoid treatment suppresses HPA axis activity, causing atrophy of the adrenals and a failure to mount an adequate response during stress (potentially fatal) and following treatment withdrawal. Understanding the mechanisms resulting in HPA axis failure may allow us to predict those at risk, inform treatment str...

ea0015p6 | Bone | SFEBES2008

Sunlight deficiency: a reversible cause of low serum phosphate?

Chambers Thomas , Heald Adrian , Radford Daniela , Waldron Julian , Davies Marten , Baines Malcolm

Background: Vitamin D3 is generated in the skin of humans from 7-dehydrocholesterol by ultraviolet light. Vitamin D3 is hydroxylated to its metabolically active form in the liver and kidneys. The hydroxylated form of Vitamin D3, is required for both phosphate and calcium absorption in the gut and reabsorption from the kidneys. Vitamin D deficiency is associated with a low circulating calcium and phosphate.Case report: A 5...

ea0031p295 | Pituitary | SFEBES2013

DNA methyltransferase 3a, 3b and 3L expression in fetal germ cells and its modulation

Chambers Thomas , Dean Afshan , Driesche Sander van den , Mitchell Rod , MacPherson Sheila , Anderson Richard , Drake Mandy , Sharpe Richard

Background: 5-Cytosine methylation of DNA is a means of encoding epigenetic information. In the testis, the generation of de novo methylation is conducted by the enzymes DNMT3a and 3b and the co-enzyme DNMT3L. Epigenetic marks made to the DNA of germ cells are important as a potential means of trans-generational carriage of environmental information. In fetal life, germ cell demethylation and remethylation are important physiological events and these overlap with key ...

ea0034p319 | Reproduction | SFEBES2014

Fetal glucocorticoid overexposure impacts on germline epigenetic reprogramming in the rat

Rose Catherine M , van den Driesche Sander , Boyle Ashley K , Chambers Thomas , Sharpe Richard M , Meehan Richard R , Drake Amanda J

Background: Fetal glucocorticoid overexposure is associated with low birthweight and increased cardiovascular disease risk in the offspring. Such ‘programmed effects’ can be transmitted across generations through both male and female lines. Disruption of a germline epigenetic reprogramming pathway, characterised by genome-wide erasure and subsequent re-establishment of DNA methylation, may underpin the intergenerational transmission of programmed effects. We used a r...