ea0049gp6 | Adrenal 1 | ECE2017
Cavalcante Isadora
, Nishi Mirian
, Zerbini Maria Claudia
, Chambo Jose Luiz
, Almeida Madson
, Lotfi Claudimara
, Fragoso Maria Candida
Background: The mechanisms causing hypercortisolism in primary macronodular adrenocortical hyperplasia (PMAH) are not fully clarified. The participation of ectopic receptors and autocrine/paracrine regulation of intra-adrenal ACTH in hyperplastic tissue have been considered. Additionally, germline ARMC5 mutations have been described as main cause of PMAH. So far, the functional study that analyzed the role of ARMC5 used the adrenocortical carcinoma cell line, H295R. T...