Searchable abstracts of presentations at key conferences in endocrinology

ea0021oc1.6 | Diabetes and metabolism | SFEBES2009

Testosterone improves glycaemic control, insulin resistance, body fat and sexual function in men with the metabolic syndrome and /or type 2 diabetes: a Multicentre European Clinical Trial: the TIMES2 Study

Jones Hugh , Howell Julian , Channer Kevin

Hypogonadism is a common finding in men with metabolic syndrome (MS) and/or type 2 diabetes (T2D) which adversely affects quality of life, is associated with several cardiovascular (CV) risk factors and a greater risk of mortality. Testosterone replacement therapy (TRT) in pilot studies has beneficial effects on waist circumference (WC), insulin resistance, glycaemic control, lipid and inflammatory profiles.Testosterone replacement in hypogonadal metabol...

ea0025p159 | Diabetes, metabolism and cardiovascular | SFEBES2011

Investigating the effects of testosterone on inflammatory markers of early aortic atherosclerosis in the testicular feminised mouse (Tfm) model

Kelly Daniel , Sellers Donna , Woodroofe Nicola , Jones Hugh , Channer Kevin

Objectives: The over-recruitment and activation of leukocytes characteristic of early atherosclerosis is considered the driving force behind atheroma development and is regulated by the concerted activities of several cytokines, chemokines and adhesion molecules surrounding a lipid core. Low serum testosterone levels are associated with cardiovascular disease in men and clinical trials demonstrate that testosterone replacement therapy (TRT) improves symptoms and reduces the in...

ea0015p292 | Reproduction | SFEBES2008

Testosterone and the androgen receptor CAG repeat polymorphism are correlated with leptin in men

Stanworth Roger , Kapoor Dheeraj , Channer Kevin , Jones T Hugh

Context: Obesity, diabetes and cardiovascular disease in men are associated with low testosterone levels. Leptin is produced in adipose tissue in proportion to obesity and is known to be negatively associated with testosterone in men. The shared association of testosterone and leptin with obesity is in line with the proposed adipocytokine┬ľhypogonadal┬ľobesity cycle which aims to explain the relationships between these variables.Methods: We inves...

ea0013p161 | Diabetes, metabolism and cardiovascular | SFEBES2007

HDL cholesterol levels are positively associated with testosterone and are lower with shorter androgen receptor CAG repeat lengths in men with Type 2 diabetes

Stanworth Roger , Kapoor Dheeraj , Channer Kevin , Jones T Hugh

Low testosterone levels are a common in men with coronary artery disease and Type 2 diabetes (DM2). Testosterone replacement therapy improves insulin sensitivity and glycaemic control in men with diabetes and improves numerous other cardiovascular risk factors. Interest in testosterone as a potential treatment for cardiovascular disease continues to grow. Low HDL cholesterol (HDL-C) levels are recognised as an independent cardiovascular risk factor and comprise part of the met...

ea0013p258 | Reproduction | SFEBES2007

The androgen receptor CAG repeat polymorphism is associated with serum testosterone levels and obesity in men with Type 2 diabetes

Stanworth Roger , Kapoor Dheeraj , Channer Kevin , Jones T. Hugh

Men with Type 2 diabetes have a high prevalence of low testosterone levels. Testosterone replacement therapy (TRT) has been shown to improve insulin sensitivity and glycaemic control in men with Type 2 diabetes. TRT also reduces fat mass and central obesity. The androgen receptor CAG repeat polymorphism length (AR CAG) correlates positively with transcriptional activity of the receptor as well as body fat, and insulin levels in healthy men. Most studies have not found an assoc...

ea0032p174 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Testosterone differentially regulates liver X receptor expression and targets of lipid and glucose metabolism in liver, muscle and adipose tissue of the testicular feminised mouse

Kelly Daniel , Akhtar Samia , Muraleedharan Vakkat , Brooke Johnathan , McLaren David , Channer Kevin , Jones T Hugh

Testosterone deficiency increases risk for cardiovascular disease (CVD) and type 2 diabetes. Testosterone replacement (TRT) improves insulin resistance, glycaemic control and cholesterol in hypogonadal men. Liver X receptor (LXR) is a nuclear receptor which regulates lipid and glucose metabolism. LXR agonists protect against atherosclerosis but cause hepatic steatosis. We have previously shown that TRT protects against hepatic steatosis and atherosclerosis in high-fat diet-fed...

ea0031p190 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

Testosterone differentially regulates lipid and glucose metabolism in visceral and subcutaneous fat in the testicular feminised mouse

Kelly Daniel , Muraleedharan Vakkat , Akhtar Samia , Channer Kevin , Jones T Hugh

Objectives: Testosterone deficiency is common in obese men with type 2 diabetes. Testosterone replacement therapy (TRT) improves insulin resistance, glycaemic control and cholesterol in hypogonadal men, and TRT reduces body fat mass. Adipose tissue plays a major role in glucose homeostasis and insulin sensitivity through the regulation of lipid and glucose metabolism. There are functional differences between subcutaneous and visceral adipose tissue. This study investigates the...

ea0028p182 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Testosterone Inhibits Key Enzymes of Fatty Acid Synthase and Protects Against Hepatic Steatosis in the Tfm Mouse

Kelly Daniel , Brooke Jonathan , Muraleedharan Vakkat , Akhtar Samia , Channer Kevin , Jones Hugh

Objectives: A clinical feature of insulin resistance is the development of fatty liver (hepatic steatosis). Testosterone deficiency is common in men with type-2 diabetes and is associated with insulin resistance. The testicular feminised mouse (Tfm) exhibits a non-functional androgen receptor (AR) and low circulating testosterone. We have previously shown that a high-cholesterol diet promotes hepatic steatosis in Tfm mice, and testosterone replacement therapy (TRT) attenuates ...

ea0028p211 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Effect of Testosterone on Cholesterol Synthesis and Efflux in the Liver of the Testicular Feminised (Tfm) Mouse

Kilby Elizabeth , Kelly Daniel , Akhtar Samia , Muraleedharan Vakkat , Channer Kevin , Jones Hugh

Objectives: Symptomatic hypogonadism is common in obese men with type-2 diabetes (T2DM) and metabolic syndrome (MetS), and is now an independent risk factor for cardiovascular disease. Testosterone replacement therapy (TRT) improves cholesterol metabolism in hypogonadal men with T2DM and/or MetS. We have previously shown that a non-functional androgen receptor (AR) and low levels of circulating testosterone in the testicular feminised (Tfm) mouse is associated with elevated ch...

ea0021p354 | Steroids | SFEBES2009

Low testosterone and androgen receptor insensitivity results in decreased AMP-activated protein kinase activity (AMPK) in the liver in the testicular feminised (Tfm) mouse

Igreja Susana , Nettleship Joanne E , Jones Richard D , Channer Kevin S , Jones T Hugh , Korbonits Marta

There are controversial data on the beneficial/detrimental effects on the cardiovascular as well as on the metabolic system by the sex hormone testosterone. Recent data support the hypothesis that low levels of androgens are associated with adverse cardiovascular risk factors including an atherogenic lipid profile, obesity, insulin resistance and hypertension. AMPK is a sensor of energy balance at both the cellular and whole-body level. Once activated by low energy status, it ...