Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep961 | Steroid metabolism + action | ECE2016

Increase in insuline-like growh factor levels during cross-sex hormone treatment in transgender persons

Nota Nienke , Dekker Marieke , Klaver Maartje , Wiepjes Chantal , Heijboer Annemieke , den Heijer Martin

Background: Sex steroids probably stimulate growth-hormone secretion during puberty, which in turn contributes to the development of gender specific body characteristics. Hypothetically, adequate growth hormone levels in transgender persons are also important to achieve the best therapeutic results. The influence of cross-sex hormone treatment (CHT) at growth-hormone production in adult transgender persons is not yet elucidated.Objective: To investigate ...

ea0056oc3.5 | New insights in bone disorders | ECE2018

Change in bone mineral density during the first 10 years of gender affirming hormonal treatment in transwomen and transmen

Wiepjes Chantal , de Blok Christel , Vlot Mariska , de Jongh Renate , Lips Paul , den Heijer Martin

Background: Concerns about the effects of gender affirming hormonal treatment (HT) on bone mineral density (BMD) exists, particularly for transmen with decreasing estrogen levels. HT in transpersons affects BMD on short term, but long-term follow-up studies are lacking. Therefore this study aimed to investigate the change in BMD during the first 10 years of HT in adult transwomen and transmen, in order to determine whether it is necessary to assess BMD during HT.<p class="...

ea0073aep592 | Reproductive and Developmental Endocrinology | ECE2021

Spuriously high testosterone concentrations testosterone gel users: A marker for detection

Schaper Sophie , Wiepjes Chantal , den Heijer Martin , Beukhof Carolien , Heijboer Annemieke C

ContextContamination of collected blood samples by application of testosterone gel near the venipuncture site can cause spuriously elevated serum testosterone concentrations. Often this will be detected only in case of extreme discrepancies between lab result and clinical effects. Because in vitro testosterone cannot be metabolized as the testosterone in vivo we hypothesized that measuring estradiol, as a metabolite of testosterone after aromati...

ea0056p982 | Steroid metabolism + action | ECE2018

Polycythemia in transmen – Prevalence, determinants and outcome in a large cohort

Dijk Dennis van , Wiepjes Chantal , Blok Christel de , Klaver Maartje , Nota Nienke , Tebbens Marieke , Heijer Martin den , Conemans Elfi

Introduction: Testosterone is known to have an effect on hematocrit levels, with polycythemia as an unwanted side effect. An increase in hematocrit levels is also seen in transmen after starting cross-sex hormonal treatment (CHT) with testosterone. The aim of this study is to investigate the effect of cross-sex hormonal treatment with testosterone on hematocrit levels in the context of the safety aspects of this treatment. The prevalence, determinants and outcome of secondary ...

ea0041oc11.1 | Bone &amp; Calcium Homeostasis | ECE2016

An increase of bone mineral density in male-to-female and female-to-male transgender persons after one year cross-sex hormonal treatment

Wiepjes Chantal , Vlot Mariska , Klaver Maartje , de Jongh Renate , Lips Paul , Heijboer Annemieke , Fisher Alessandra , Schreiner Thomas , T'Sjoen Guy , den Heijer Martin

Introduction: Estrogen has positive effects on bone mineral density (BMD), in particular in trabecular bone through inhibition of bone resorption. Testosterone increases bone size, but the effect on BMD is less clear. Cross-sex hormonal treatment (CSHT) in transgender individuals can affect BMD. Therefore, the aim of this study is to investigate effects of CSHT on BMD during the first year of treatment in male-to-female (MtFs) and female-to-male (FtMs) transgender persons....

ea0070aep834 | Reproductive and Developmental Endocrinology | ECE2020

Vaginal bleeding and spotting in transgender men after initiation of testosterone therapy: A prospective cohort study (ENIGI)

Defreyne Justine , Vanwonterghem Yuran , Collet Sarah , Iwamoto Sean , Wiepjes Chantal , Fisher Alessandra , Schreiner Thomas , den Heijer Martin , T’Sjoen Guy

Background: Persistent vaginal bleeding can be psychologically stressful and incongruent with gender identity in transgender men (assigned female at birth with male gender identity). Previous studieshave cross-sectionally described amenorrhea in cohorts of transgender men on intramuscular or subcutaneous testosterone injections. It remains uncertain which testosterone preparations most effectively suppress vaginal bleeding and when amenorrhea occurs after testosterone initiati...

ea0056gp222 | Reproduction | ECE2018

Change in visceral fat and its relation with change in lipids in trans persons during hormonal therapy: results from a multicenter prospective study

Klaver Maartje , Wiepjes Chantal , de Blok Christel , Nota Nienke , Defreyne Justine , Schneider Thomas , Fisher Alessandra , T'Sjoen Guy , den Heijer Martin , de Mutsert Renee

Introduction: Excess visceral adipose tissue (VAT) is strongly related to multiple cardiovascular risk factors such as dyslipidemia. Hormonal therapy (HT) in trans persons affects total body fat and body fat distribution, but the effect on VAT and its relation to changes in lipids is unknown. The aim of our study was to investigate the effect of one year HT on changes in VAT and its relation with changes in total cholesterol, HDL, LDL, and triglycerides after one year of HT.</...

ea0056p955 | Female Reproduction | ECE2018

Breast cancer in transgender persons receiving gender affirming hormone treatment: results of a nationwide cohort study

JM de Blok Christel , Wiepjes Chantal M. , Nota Nienke M. , Engelen Klaartje van , Adank Muriel A. , Dreijerink Koen M.A. , Barbe Ellis , Konings Inge R.H.M. , den Heijer Martin

Background: Transpersons can receive gender affirming hormone therapy (HT) to induce physical changes. Little is known about the effect of HT on breast cancer (BC) risk.Objectives: To study the prevalence and characteristics of BC in transpersons with HT and to compare this prevalence with the general Dutch male and female population.Methods: Adult transpersons who were seen after 1991 and started HT in the VUmc were included. This...