Searchable abstracts of presentations at key conferences in endocrinology

ea0077p136 | Adrenal and Cardiovascular | SFEBES2021

Glucocorticoid receptor activation regulates cardiomyocyte cell cycle in neonates

Ivy Jessica , Urquijo Helena , Mort Richard , Chapman Karen

In neonates, cardiomyocytes exit the cell cycle thus establishing cardiomyocyte number for life. Further growth is through hypertrophy. Factors that advance the timing of the switch from hyperplastic to hypertrophic growth may increase risk of cardiac disease in adulthood. Early life administration of glucocorticoids is known to increase risk of cardiovascular disease. We hypothesized that dexamethasone, a synthetic glucocorticoid, causes precocious cell cycle exit of neonatal...

ea0018p31 | (1) | MES2008

Diagnostic cut-off for calcitonin: is 10 ng/l still valid?

Ramachandran Radha , Benfield Patricia , White Sara , Chapman Richard , Meeran Karim , Donaldson Mandy , Martin Niamh

Aim: Population studies have shown that basal calcitonin concentrations are below 10 ng/l in the normal population. Ten nanograms per liter is used as a diagnostic cut-off by most laboratories and patients with levels higher than this are offered a pentagastrin stimulation test to exclude medullary thyroid carcinoma. However, these guidelines were adopted from studies that used the Cisbio Immunoradiometric assay for measuring calcitonin. Most laboratories have now moved to che...

ea0021p118 | Clinical practice/governance and case reports | SFEBES2009

Salivary cortisol is a reliable marker to monitor hydrocortisone replacement

Pahilwani Bharat , Darch Sarah , Ramachandran Radha , Cegla Jaimini , Nijher Monica , Meeran Karim , Chapman Richard , Donaldson Mandy , Tan Tricia

Context: Hydrocortisone day curves (HCDC) are used to monitor hydrocortisone replacement by obtaining serum samples to measure cortisol levels throughout the day. Salivary measurement of free cortisol offers a non-invasive alternative to serum measurements.Objective: To validate salivary cortisol measurement as an alternative method to assess the adequacy of hydrocortisone replacement in patients with hypoadrenalism.Setting, patien...