Endocrine Abstracts

Background: Treatment of primary hyperparathyroidism (PHPT) and secondary hyperparathyroidism due to idiopathic hypercalciuria (SHPT-IH) is markedly different. Nevertheless, differentiating one from another remains a challenge and robust diagnostic tools are lacking. The thiazide challenge test (TCT) has been proposed as a means to aid clinicians in their decision making. However, evidence supporting its use is scarce.Materials and Methods: We performed ...

Objective: Acromegaly is often accompanied by abnormalities in glucose and lipid metabolism, which tend to ameliorate upon treatment. However, few studies have investigated whether glucose homeostasis and lipid profiles are differently affected by different treatment regimens. This study aimed to compare glucose homeostasis and lipid profiles in patients with acromegaly who are well-controlled after surgery or under stable treatment with long-acting somatostatin analogs (SSA) ...

Background: Pegvisomant has demonstrated efficacy in attaining IGF1 normalisation in previously uncontrolled acromegalic patients. A home care programme improves treatment compliance.Aims: Evaluation of home educational program and quality of life (Qol).Methods: Multicentre observational study involving eight Flemish centres. Uncontrolled acromegalic out-patients were trained for daily subcutaneous pegvisomant injection at home by ...

A 22-year old female is followed at our department because of genetically confirmed autoimmune polyendocrine syndrome type 1 (APS-1). This was diagnosed at the age of 9 and in this patient characterized by autoimmune hypoparathyroidism, autoimmune hepatitis, autoimmune gastritis and premature ovarian insufficiency. Throughout childhood and puberty, the hypoparathyroidism was treated with moderate doses of calcium citrate (~3g/d) and calcitriol (~1.5µg/d), nevertheless res...

Aim: To investigate the relationship of arterial stiffness with short- and long-term parameters of glycemic control and glycation in patients with type 1 diabetes.Methods: Cross-sectional study at a tertiary care centre including 54 patients with type 1 diabetes free from known CVD. Arterial stiffness was assessed with carotid-femoral pulse wave velocity (cf-PWV). Current level and 10-years history of HbA1c was evaluated, and skin advanced glycation end-...

Background: Bone turnover markers are used in research and clinical practice, but only in part reflect bone formation and resorption. Components of the Wnt-signaling pathway, regulating osteoblastogenesis and osteoblast function, can be measured in serum, however it is unclear whether they reflect underlying bone mass and metabolism.Objective: Determine whether serum levels of Wnt-signalling components reflect bone mass or metabolism in men during growth...

Background: Impaired bone geometry and/or aberrant bone matrix formation may underlie the increased fracture risk observed in patients with type 1 diabetes mellitus (T1DM). Although reduced areal and volumetric bone mineral density (aBMD, vBMD) have been observed in pediatric and adolescent T1DM patients, few studies have confirmed these observations in adults. Moreover, data on bone geometry in T1DM remain scarce.Objective: To compare areal and volumetr...

Objective: In type 2 diabetes mellitus, fracture risk is increased despite preserved BMD. This might in part be due to insulin resistance affecting bone geometry; however, studies investigating the associations of insulin sensitivity with bone geometry are lacking. We aimed to explore this relationship in a cohort of healthy, young adult men.Methods: In 1001 healthy men aged 25–45 years, cortical bone geometry was assessed using pQCT (radius and tib...

Gender dysphoria (GD) leading to hormonal treatment and sex reassignment surgery that spans two generations has not been reported so far.The mother was diagnosed with GD at the age of 47. As an only child she suffered from emotional, physical, and sexual abuse by her parents. From the age of 3, she fantasized being a boy and started behaving like one. During later youth the genderdysphoric feelings were repressed. She married at the age of 18. One year l...

Bone metabolism in men is in part determined by sex steroid exposure. This is especially clear during puberty and senescence but it remains to be established whether declines in sex steroid levels during young and middle adulthood associate with changes in bone mass and size. This study investigated changes in bone mineral content (BMC), areal and volumetric bone density (aBMD; vBMD) and bone size in relation to sex steroid levels in 999 young adult men (age 24- 46 years) of w...