Searchable abstracts of presentations at key conferences in endocrinology

ea0002sp6 | The Endocrinology of Syndrome X | SFE2001

PPAR gamma and human insulin resistance

Chatterjee V

Adiposity is a major risk factor for insulin resistance and type 2 diabetes. PPAR gamma, an orphan nuclear receptor, is highly expressed in adipose tissue. Paradoxically, synthetic PPAR gamma ligands including thiazolidinedones (TZDs), which activate PPAR gamma induce adipogenesis yet improve insulin sensitivity. We have shown that TZDs selectively induce human subcutaneous but not omental preadipocyte differentiation in vitro, correlating with the observation that trea...

ea0007p180 | Reproduction | BES2004

Peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists increase glucose metabolism in a human granulosa cell line (HGL-5)

Berdiaki A , Chatterjee V , Rainey W , Franks S

Ligand-activated peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear hormone receptor, dimerises with retinoid X receptor(RXR) and acts as a transcription factor translating nutritional, pharmacological and metabolic stimuli into changes in gene expression. PPARgamma is thought to serve several roles in adipocyte differentiation, fatty acid and lipid metabolism, insulin sensitivity and ovarian steroidogenesis. PPARgamma has also been shown to increase gluco...

ea0028p347 | Thyroid | SFEBES2012

Rheumatoid Factor interference in TSH assays

Bacon Olivia , Lowery Sarah , Halsall Ian , Chatterjee V , Halsall David

Heterophilic antibody interference in serum TSH immunoassays can result in misdiagnosis of patients with suspected thyroid disease. Rheumatoid factor (RhF) is an immunoglobulin with reactivity to the Fc portion of human IgG. Some RhF species also cross-react with animal immunoglobulins so have the potential to act as heterophile antibodies. As part of the Cambridge Supra-Regional Assay service for thyroid function testing five serum samples with strongly positive RhF and posit...

ea0007p58 | Diabetes, metabolism and cardiovascular | BES2004

Targeted RNA interference to selectively modulate expression of PPARgamma2 and 1 isoforms

Schoenmakers E , Hadaschick D , O'Rahilly S , Chatterjee V

The PPARgamma is a ligand activated transcription factor that plays an important role in various biological processes including adipocyte differentiation and glucose homeostasis. Alternate promoter usage generates two receptor isoforms: PPARgamma2, containing 28 additional aminoterminal residues, is selectively expressed in adipose tissue whereas PPARgamma1 is more ubiquitously distributed. PPARgamma2 is strongly up regulated during adipogenesis, suggesting a specific role for...

ea0005oc1 | Reproduction and Development | BES2003

Agonists of peroxisome proliferator-activated receptor-gamma (PPARgamma) regulate steroidogenesis in a human granulosa cell line (HGC-5)

Berdiaki A , Jonard S , Chatterjee V , Rainey W , Franks S

Peroxisome proliferator-activated receptor-gamma (PPARgamma) is one of the isoforms of the PPAR-family of nuclear hormone receptors. Ligand activated PPARs dimerise with retinoid X receptor and act as transcription factors translating nutritional, pharmacological and metabolic stimuli into changes in the expression of genes. PPARgamma is thought to serve several roles in adipocyte differentiation, fatty acid and lipid metabolism and insulin sensitivity. PPARgamma has also been...

ea0036P83 | (1) | BSPED2014

Congenital central hypothyroidism due to a TSHB mutation with uniparental inheritance

Nicholas Adeline K , Jaleel Safia , Schoenmakers Erik , Dattani Mehul , Roche Edna , Chatterjee V Krishna , Schoenmakers Nadia

Introduction: Biallelic mutations in the TSHB gene are a recognized cause of isolated congenital central hypothyroidism (CH), with autosomal recessive inheritance. In countries where neonatal CH screening relies on detection of an elevated TSH, such cases are missed, with the potential for delayed diagnosis and subsequent developmental impairment.Case: A female infant presented aged 8 weeks with prolonged jaundice, poor weight gain, constipation...

ea0031p360 | Thyroid | SFEBES2013

Homozygous resistance to thyroid hormone: can cardiac complications be prevented?

Moran Carla , Al-Johani Amal , Rajanayagam Odelia , Halsall David , Habeb Abdelhadi , Chatterjee V K K

Resistance to thyroid hormone (RTH) is usually due to heterozygous mutations in THRB gene with rare cases being homozygous for receptor defects. We describe an RTH case due to a homozygous TRβ mutation (R243Q).The Proband (male, 8.4 years), was born at term with low birth weight (1.9 kg) to consanguineous parents. He has a prominent nasal bridge, goitre, low body weight (10th centile), recurrent tonsillitis, hyperactivity and has mild hearing impair...

ea0031p365 | Thyroid | SFEBES2013

The challenge of managing refractory amiodarone-induced Graves' disease in resistance to thyroid hormone

Moran Carla , Chatterjee V K K , Page M D , Owen Penny

A 42-year-old man with resistance to thyroid hormone (RTH) and a recognised thyroid hormone receptorβ mutation (R383C) mutation, presented with atrial fibrillation (AF) which was resistant to DC cardioversion until initiation of amiodarone therapy.As expected in RTH, his baseline TFTs were abnormal (FT4 34.6 pmol/l, TSH 2.27 mU/l), but rose further (FT4 45 pmol/l, TSH 0.93 mU/l) following commencement of amiodarone. However, sh...

ea0019p173 | Endocrine tumours and neoplasia | SFEBES2009

Metastatic insulinoma with persistent hypoglycaemia

Geevarghese C , Lim M , Sirohi B , Appleton D , Chatterjee V , Simpson H

A 67-year-old lady presented with hypoglycaemic coma, treated with dextrose infusion. Previously she had a 3-month history of weight gain with increasingly frequent episodes of shaking and blurred vision, particularly at night, relieved by food.A 72-hour fast was undertaken. Within 2 h, she became confused. Serum glucose was 1.1 mmol/l with serum insulin 527 pmol/l (0–60 pmol/l), proinsulin 320 pmol/l (0–7 pmol/l) and C-peptide 2991 pmol/l (174...

ea0007p283 | Clinical case reports | BES2004

A case of undiagnosed multiple endocrine neoplasia type 2B (MEN 2B)

Myint K , Wiles A , Marker A , Jani P , Middleton S , Chatterjee V , Gurnell M

Multiple Endocrine Neoplasia Type 2B is a dominantly inherited disorder characterised by mucosal neuromas, medullary thyroid carcinoma (MTC), phaeochromocytoma, and intestinal ganglioneuromatosis. We report the case of a 34-year-old woman who presented with chronic diarrhoea. She had a longstanding history of gastrointestinal symptoms including diarrhoea since the age of 7 and had been investigated extensively for over 20 years at three different centres, but no definitive dia...