Searchable abstracts of presentations at key conferences in endocrinology

ea0075t10 | Thyroid | EYES2021

Mutational profile of a series of sporadic medullary thyroid carcinoma patients with metastatic - persistent disease

Simeakis George , Korkolopoulou P. , Chatziandreou H. , Chatzigianni C. , Paschou S. , Alevizaki M. , Saltiki K.

Background: Tyrosine Kinase Inhibitors show great promise in the management of metastatic Medullary Thyroid Carcinoma.Somatic mutations are considered to play a major role in the response/resistance to therapies.RET-somatic mutations are present in 45-75% of sporadic MTCs while RAS are rarer.Objectives: The aim of this study is to investigate the mutational profile of 18 spMTC pts, with metastatic/biochemical persistent disease and to look into possible ...