Searchable abstracts of presentations at key conferences in endocrinology

ea0026p102 | Female reproduction | ECE2011

The importance of PIK3R1 gene in polycystic ovary syndrome

Xita N , Chatzikyriakidou A , Georgiou I , Tsatsoulis A

Introduction: Insulin resistance is a main characteristic of polycystic ovary syndrome (PCOS) and contributes to the increased risk of type 2 diabetes and cardiovascular disease. It is thought that in PCOS there is an alteration in the insulin signaling pathway. An important kinase in this pathway is the phosphatidylinositol 3 kinase (PI3K), the activity of which has been found to be decreased in PCOS. Based on this observation we investigated whether a single nucleotide polym...

ea0020p362 | Diabetes and Cardiovascular | ECE2009

Klotho gene polymorphism may be a genetic risk factor for metabolic syndrome in men

Katsoulis Constantinos , Chatzikyriakidou Anthi , Xita Nektaria , Georgiou Ioannis , Tsatsoulis Agathocles

Introduction: Klotho has an important role in insulin signaling and the development of ageing-like phenotypes in mice. Recently, the G-395A polymorphism in the promoter region of the human klotho gene has been reported to affect promoter function. It has been also shown to be an independent genetic risk factor for atherosclerotic cardiovascular disease. The aim of this study was to examine the possible role of this polymorphism in the metabolic syndrome....

ea0016p638 | Reproduction | ECE2008

The importance of the (TTTA)n polymorphism of aromatase (CYP19) gene in menarche

Xita Nectaria , Chatzikyriakidou Anthoula , Stavrou Ioanna , Zois Chris , Georgiou Ioannis , Tsatsoulis Agathocles

Background of study: Twin studies have shown that age at menarche may be subject to hereditary influences but the specific determinants are unknown. Estrogens are known to have an important role in menarche. Since aromatase is responsible enzyme for the conversion of androgens to estrogens, the aromatase (CYP19) gene could be a candidate gene for the regulation of menarche. The aim of this study was to investigate the possible association of the CYP19(TTTA)n poly...