Searchable abstracts of presentations at key conferences in endocrinology

ea0020p362 | Diabetes and Cardiovascular | ECE2009

Klotho gene polymorphism may be a genetic risk factor for metabolic syndrome in men

Katsoulis Constantinos , Chatzikyriakidou Anthi , Xita Nektaria , Georgiou Ioannis , Tsatsoulis Agathocles

Introduction: Klotho has an important role in insulin signaling and the development of ageing-like phenotypes in mice. Recently, the G-395A polymorphism in the promoter region of the human klotho gene has been reported to affect promoter function. It has been also shown to be an independent genetic risk factor for atherosclerotic cardiovascular disease. The aim of this study was to examine the possible role of this polymorphism in the metabolic syndrome....