Endocrine Abstracts

Long-term exposure to cortisol carry health risk and its important to establish the cause and exclude exogenous steroid use before starting investigation for endogenous causes, we present a young man with clinical picture of Cushing but low random cortisol.16 years old studying for his AS examinations at the time, presented to his GP with 5-week history of fatigue, weight gain of 2 stone in 18 months, insomnia, diarrhoea, left ...

Long-term exposure to cortisol carry health risk and its important to establish the cause and exclude exogenous steroid use before starting investigation for endogenous causes, we present a young man with clinical picture of Cushing but low random cortisol.16 years old studying for his AS examinations at the time, presented to his GP with 5-week history of fatigue, weight gain of 2 stone in 18 months, insomnia, diarrhoea, left ...

Disorders of calcium metabolism are common in Sarcoidosis. The frequency of hypercalciuria and hypercalcaemia has been reported as 30–50% and 10–20% respectively. The underlying mechanism is enhanced PTH independent extra-renal production of 1,25-Dihydroxy Vitamin D (Calcitriol) which increase absorption of Calcium from the gut causing hypercalcaemia.A 79 year old lady was admitted with fever, cough and night sweats and was treated for pneumoni...

The milk – alkali syndrome was well known in the pre-proton pump inhibitor era when remedies for peptic ulcer included a large amount of calcium and sodium bicarbonate resulting in hypercalcaemia, metabolic alkalosis and often acute kidney injury. In a study done from 1998 to 2003, milk alkali syndrome was the cause of hypercalcaemia in 8.8 percent of the cases which is a significant percentage, so awareness about it is important.<p class="abste...

Moyamoya disease is a progressive chronic neurological disease due to multiple narrowing of the carotid arteries. It can be seen in association with atherosclerosis, vasculitis, haematological conditions, connective tissue disease, neurocutaneous syndromes and certain autoimmune diseases. Very few cases have been reported in association with Graves disease and the majority being in the East Asian population. We present a rare case of this association in a young C...

The milk – alkali syndrome was well known in the pre-proton pump inhibitor era when remedies for peptic ulcer included a large amount of calcium and sodium bicarbonate resulting in hypercalcaemia, metabolic alkalosis and often acute kidney injury. In a study done from 1998 to 2003, milk alkali syndrome was the cause of hypercalcaemia in 8.8 percent of the cases which is a significant percentage, so awareness about it is important.<p class="abste...

Moyamoya disease is a progressive chronic neurological disease due to multiple narrowing of the carotid arteries. It can be seen in association with atherosclerosis, vasculitis, haematological conditions, connective tissue disease, neurocutaneous syndromes and certain autoimmune diseases. Very few cases have been reported in association with Graves disease and the majority being in the East Asian population. We present a rare case of this association in a young C...

Audit standard: All patients should receive written and verbal advice about the risk of neutropenia associated with the use of anti-thyroid drugs. Compliance rate 100%.Our Endocrinology Department has a detailed patient information sheet that is provided to the patients at the time of initiation of anti-thyroid drugs.Background: Recently, a patient was admitted with neutropenia secondary to the use of carbimazole. She did not know ...

Section 1: Case history: This 41 year old lady was seen in the Endocrine clinic with an 8 year history of worsening hypertension, obesity and Type 2 diabetes. She had no conditions known to cause physiological hypercortisolism, no exogenous steroid use and had clear physical features of Cushing’s syndrome.Section 2: Investigations: Investigations confirmed Cushing’s syndrome with two elevated urinary free cortisol assessments (UFC) (934 and 906...

Hyponatremia is the commonest electrolyte abnormality presenting to Medical Admissions and when acute, severe and symptomatic, is associated with high mortality. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common underlying disorder in hospitalised patients with euvolaemic hyponatraemia and is a complication of many clinical conditions and drug therapies.We discuss the cases of two patients...