Searchable abstracts of presentations at key conferences in endocrinology

ea0011p891 | Thyroid | ECE2006

Regulation of fibroblast growth factor receptor-1 (FGFR1) by thyroid hormone (T3): identification of a thyroid hormone response element (TRE) in the murine Fgfr1 promoter

O’Shea PJ , Williams GR , Cheng SY

T3 is essential for skeletal development and T3-actions in bone are mediated mainly by the nuclear receptor TRα1. We previously identified that FGFR1 is a T3-responsive gene in osteoblasts by subtraction hybridization. In mice that harbor a dominant negative mutation PV, FGFR1 mRNA expression is reduced in TRα1PV mutants that exhibit skeletal hypothyroidism and increased in TRβPV/PV mice with skeletal thyrotoxicosis. In this study, primary ...

ea0011p896 | Thyroid | ECE2006

Isometric tension studies in a transgenic mouse model of thyroid hormone resistance

Owen PJD , Tomlinson D , Ying H , Lang D , Cheng SY , Lazarus JH

Thyroid hormone resistance (THR) is associated with elevated FT4 and FT3 with inappropriately high TSH levels. T3 action is mediated by two types of thyroid hormone receptor, encoded by alpha and beta genes. We evaluated the endothelial function of a THR transgenic mouse model with a targeted mutation in the thyroid hormone beta receptor gene ex vivo.Isometric tension of aortic rings of 10 mice of each genotype (TRbPV/PV, TRbPV/+</...