Searchable abstracts of presentations at key conferences in endocrinology

ea0044p38 | Adrenal and Steroids | SFEBES2016

18F-FDG PET-CT combined with 11C-metomidate PET-CT for the successful characterisation of adrenal lesions; proof of utility of a novel imaging strategy in guiding management

Powlson Andrew S , Koulouri Olympia , Cheow HK , Gurnell Mark

Background/aims/method: Evaluation/management of adrenal incidentalomas (AI) is an increasingly prevalent challenge. CT/MRI characteristics may be useful in determining whether a lesion is a benign adenoma and forthcoming ESE-ENSAT guidance suggests a role for 18F-FDG-PET/CT in distinguishing benign vs malignant lesions. We have previously demonstrated the utility of 11C-metomidate (MTO), which binds CYP11B1/B2, in localising aldosterone-producing adenoma...

ea0031p263 | Pituitary | SFEBES2013

11C-methionine PET–CT co-registered with volume MRI identifies residual functioning tumour in acromegaly

Koulouri Olympia , Kandasamy Narayanan , Moran Carla , Chatterjee Krish , Halsall David , Cheow HK , Antoun Nagui , Hoole Andrew , Burnet Neil , Donnelly Neil , Mannion Richard , Pickard John , Gurnell Mark

Although MRI remains the investigation of choice for pituitary imaging, it does not reliably identify all secretory microadenomas, and cannot always discriminate residual tumour from post-surgical change following hypophysectomy. We hypothesised that i) imaging with the PET ligand 11C-methionine, which is taken up at sites of peptide/protein synthesis, would permit more reliable identification of functioning pituitary adenoma, and ii) co-registration of PET–CT ...