Searchable abstracts of presentations at key conferences in endocrinology

ea0081p478 | Thyroid | ECE2022

Thyroid nodules and glucose metabolism derangements: does sex matter?

Gagliardi Irene , Gobbo Alberto , ROSSI ROBERTA , Rossi Martina , Rosaria Ambrosio Maria , Chiara Zatelli Maria

Background: Glucose metabolism derangements (GMD) and thyroid nodules (TN) are the most frequent endocrine disorders. A relationship between these conditions has been suggested, but data are still controversial and no evidence was reported regarding sex differences.Aim: To evaluate the distribution of impaired fasting glucose (IFG), normal glucose tolerance (NGT), impaired glucose tolerance (IGT), type 2 diabetes (T2DM) and TN according to sex.<p cla...

ea0090p664 | Endocrine-related Cancer | ECE2023

Mutational profiles of typical and atypical bronchial carcinoids

Gagliardi Irene , Borges de Souza Patricia , Rossi Lucrezia , Rosaria Ambrosio Maria , Chiara Zatelli Maria

Introduction: Typical and Atypical bronchial carcinoids (TBC and ABC) are rare neuroendocrine neoplasms (NEN). TBC are low grade and well-differentiated NEN often with indolent clinical behavior, slow growth, rare extra-thoracic metastases, and with a long survival following surgical resection. Conversely, ABC have often a worse prognosis with a greater tendency to metastasize and recur. A better understanding of TBC and ABC genetic background would help in evaluating prognosi...

ea0049ep196 | Neuroendocrinology | ECE2017

Identification of molecular targets of Sunitinib in pancreatic neuroendocrine tumours

Bresciani Giulia , Gagliano Teresa , Hofland Leo J , Gentilin Erica , Falletta Simona , Riva Eleonora , Chiara Zatelli Maria

: Pancreatic neuroendocrine tumours (pNETs) are rare neoplasms arising from the endocrine pancreas. The fist line treatment is surgery that is often not curative in the presence of metastatic disease. Therefore, there is an increasing need for medical therapy. Sunitinib is a multi-target receptor tyrosine-kinase (RTK) inhibitor, described as having as main target VEGF receptor, with antitumor and antiangiogenic effects, approved for pNETs medical treatment. This study is aimed...

ea0049ep197 | Neuroendocrinology | ECE2017

Study of different in vitro systems for the evalutation of Sunitinib effects in pancreatic neuroendocrine tumour cells

Bresciani Giulia , Gagliano Teresa , Hofland Leo J , Gentilin Erica , Falletta Simona , Riva Eleonora , Chiara Zatelli Maria

Finding new preclinical models to study the effects of anticancer drugs is one of the aims of biomedical research. Indeed, testing different in vitro systems can lead to a better understanding of the molecular pathways regulating tumor development and growth, and help to find new therapeutic approaches. This is crucial especially in the settings of pancreatic neuroendocrine tumours (pNET), where one of the main drugs approved for medical treatment is Sunitinib, a mult...

ea0070aep603 | Pituitary and Neuroendocrinology | ECE2020

TGF-β increases caspase 3 activation and migration in bronchial carcinoids

Borges de Souza Patricia , Tagliatti Valentina , Capobianco Simonaco , Rosaria Ambrosio Maria , Chiara Zatelli Maria

Introduction: Typical and atypical bronchial carcinoids (TBC and ABC) are well-differentiated neuroendocrine neoplasms (NEN). First-line treatment is radical removal of the primary tumour; however, management of metastatic BC is still challenging. Bronchial carcinoids (BC) may benefit from treatment with mTOR inhibitors, although response rates are moderate. TBC have shown reduced sensibility to mTOR inhibitors respect to ABC, notwithstanding its less aggressive behaviour. PI3...

ea0070ep445 | Thyroid | ECE2020

Clustering techniques for thyroid nodules malignancy inference in the era of personalized medicine

Giani Andrea , Borges de Souza Patricia , Bartoletti Stefania , Morselli Flavio , Conti Andrea , Chiara Zatelli Maria

Introduction: Thyroid nodules (TN) are common entities usually discovered during a physical exam or by chance with ultrasound (US) procedures performed for reasons different from thyroid check. The majority of nodules are benign, notwithstanding the growing incidence of thyroid cancer (TC), which increases much largely as compared to all other tumours each year and will be, presumably, the most incident malignancy in women after breast cancer. The clinical challenge relies on ...

ea0032p829 | Pituitary–Basic (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

mTOR mediated IGF1 proliferative effects on a rat pituitary GH/PRL secreting pituitary adenoma cell line

Bellio Mariaenrica , Mirabassi Cecilia , Gagliano Teresa , Uberti Ettoredegli , Chiara Zatelli Maria

IGF1 represents an important growth factor in pituitary physiology and pathology, also mediating the negative feed-back mechanisms on somatotroph axis. It has been previously demonstrated that IGF1 promotes cell viability in primary cultures of human non functioning pituitary adenomas, by a mechanisms involving, at least in part, mTOR signaling, which is involved in many pathways controlling proliferation. We aimed at investigating whether mTOR may mediate IGF1 effects also in...

ea0073pep5.2 | Presented ePosters 5: Thyroid | ECE2021

Low-risk papillary thyroid carcinoma: outcome predictive factors in a cohort of patients not treated with radioiodine therapy after total thyroidectomy

Gagliardi Irene , Mella Alessandro , Rossi Roberta , Pontrelli Margherita , Rossi Martina , Chiara Zatelli Maria

BackgroundPapillary thyroid carcinoma (PTC) is the most frequent thyroid malignant neoplasm. American Thyroid Association (ATA) guidelines don’t specify how to follow-up low-risk PTC patients not receiving radioiodine therapy (RAI) after total thyroidectomy (TT). Indeed, there is no consensus among authors regarding the interpretation of thyroglobulin (TG) levels and ultrasound neck (US) findings during follow-up in these settings.<p class="abst...

ea0073aep723 | Thyroid | ECE2021

Thyroid morphologic characteristics assessment in a cohort of patients with different glucose tolerance status

Gagliardi Irene , Dinatolo Elisa , Franceschetti Paola , Mella Alessandro , Lupo Sabrina , Chiara Zatelli Maria

BackgroundThyroid diseases and diabetes are the two most common endocrinopathies. A relationship between these two conditions is suggested by many studies, as diabetic population seems to present increased thyroid impairment. However, clinical data are still very sparse.AimTo evaluate thyroid morphologic characteristics among patients with different glucose tolerance status.Material and...

ea0049ep789 | Endocrine tumours and neoplasia | ECE2017

Magmas modulates chemoresistance in endocrine-related cancers

Riva Eleonora , Tagliati Federico , Gagliano Teresa , Trapella Claudio , Missiroli Sonia , Pinton Paolo , Bertolucci Cristiano , degli Uberti Ettore , Chiara Zatelli Maria

: Magmas, a gene encoding for the mitochondrial import inner membrane translocase subunit, Tim16, protects different cell lines from the antitumoral effects of several pro-apoptotic stimuli (i.e. chemicals and chemotherapeutic agents). The synthetic Compound 5 is capable of sensitizing chemoresistant tumor cells overexpressing Magmas to proapoptotic stimuli, indicating that this molecule may be useful to overcome tumor chemoresistance. The aim of our study was to evaluate whet...