Searchable abstracts of presentations at key conferences in endocrinology

ea0021p271 | Pituitary | SFEBES2009

The effect of pituitary surgery on VEGF, MMP 2 and MMP 9 levels in acromegaly and non-functioning pituitary adenomas

Chirayath Haiju , Hoppmann Julia , Randeva Harpal , Wass John

Background: Serum biomarkers which correlate with pituitary tumour growth would be valuable in the treatment and follow-up of patients with pituitary adenomas, particularly non-functioning adenomas. Vascular Endothelial Growth Factor (VEGF) mRNA is upregulated in almost all tumours, whereas matrix metalloproteinases 2 and 9 (MMP 2 and 9) have been demonstrated to be important in tumour vascularisation and invasion, particularly in prolactinomas.Aim: The ...

ea0021p274 | Pituitary | SFEBES2009

Rathke's cleft cysts in need of regular follow-up in case of recurrence

Trifanescu Raluca , Mandecka Alexandra , Chirayath Haiju , Ansorge Olaf , Cudlip Simon , Wass John AH , Karavitaki Niki

Background: Rathke’s cleft cysts (RCC) are benign, cystic lesions arising from remnants of Rathke’s pouch and reported in 13–22% of normal autopsies. Their prognosis after surgical intervention is not clearly defined.Aim: To analyse the outcome of patients who presented to our Department with RCC between 1/1977-3/2009.Patients and methods: Thirty-three cases were identified [13 males/20 females, median age at diagnos...