Searchable abstracts of presentations at key conferences in endocrinology

ea0029p752 | Endocrine Disruptors | ICEECE2012

Treatment with resveratrol resulted in an inhibition of cell proliferation induced by 17 β-estradiol or various endocrine disrupting chemicals via down-regulating the cell cycle progression in BG-1 ovarian cancer cells

Kang N. , Hwang K. , Choi K.

Resveratrol (trans-3,4,5-trihydroxystilbene, RES), a phytoestrogen, exists in grape skin and red wine. Endocrine disrupting chemicals (EDCs) appear to promote the development and progression of the estrogen dependant cancers. In this study, we evaluated the inhibitory effect of RES on the cell growth and progression induced by various EDCs in BG-1 ovarian cancer cells expressing estrogen receptors (ERs). The various EDCs, i.e., bisphenol A (BPA), nonylphenol (NP), octylphenol ...

ea0029p751 | Endocrine Disruptors | ICEECE2012

Bisphenol A and phthalate stimulated the growth of human prostate cancer cells and altered downstream target genes of ras signaling pathway

Kim K. , Lee H. , Choi K.

Prostate cancer have been most cause of cancer death to men in recent, but there are not effective treatments for this cancer. In growth of prostate cancer, steroid hormones such as androgen play a role in their growth and survival. However, endocrine disrupting chemicals (EDCs) intend to bind the hormone receptor and induce the abnormal hormone response. EDCs have potency to activate estrogen receptor (ER) and androgen receptor (AR) mediated signaling pathways, and they cause...

ea0029p754 | Endocrine Disruptors | ICEECE2012

Synergistic effects of bisphenol A and paraben on the induction of calbindin-D9k and progesterone receptors via an estrogen receptor pathway in rat pituitary GH3 cells

Jung E. , Choi K. , Jeung E.

Introduction: There are concerns about the combined estrogenic effects of endocrine disrupting chemicals (EDCs), since mixtures of these chemicals exist in our environment. This study investigated potential synergistic interactions between bisphenol A (BPA) and isobutylparaben (IBP), which are major xenoestrogens used in the manufacture of plastics, cosmetics, drugs, and other products. The combined effects of these two chemicals were analyzed by measuring expression of calbin...

ea0029p756 | Endocrine Disruptors | ICEECE2012

A phytoestrogen, genistein, reversed 17 β-estradiol or bisphenol A-induced cell growth via downregulation of the cell cycle progression in BG-1 ovarian cancer cells

Hwang K. , Kang N. , Choi K.

One of estrogens, 17b-estradiol (E2), is a pleiotropic hormone that regulates the growth and differentiation of many tissues and also acts as a mitogen that promotes the development and proliferation of hormone-responsive cancers. Bisphenol A (BPA) is a widely used industrial compound and classified as one of endocrine disrupting chemicals (EDCs) and especially a xenoestrogen that imitates estrogen in living organisms. In this study, we examined the effect of a phytoestrogen, ...

ea0029p749 | Endocrine Disruptors | ICEECE2012

Octylphenol and triclosan induced proliferation of human breast cancer cells via an estrogen receptor-mediated signaling in vitro

Lee H. , Park M. , Yi B. , Choi K.

The class of endocrine disrupting chemicals (EDCs) is comprised of both naturally occurring and man-made compounds which are structurally similar or distinct to estrogen, and can interfere with the actions of an endogenous steroid hormone via estrogen receptors (ERs). Octylphenol (OP) is alkyl phenol chemical, which is considered to be a low-level endocrine disruptor owing to its tendency to mimic estrogen. It has been reported that triclosan can cause endocrine disruption and...

ea0029p750 | Endocrine Disruptors | ICEECE2012

Endocrine disrupting chemicals induced alteration of cell cycle related genes resulting in proliferation of human breast cancer cells via an estrogen receptor-mediated signaling pathway in vitro

Lee H. , Yi B. , Jeung E. , Choi K.

Endocrine disrupting chemicals (EDCs) have brougt the growing concern about the potential to interfere with the endocrine system and to cause health problems. Among EDCs, bisphenol A (BPA) and 1,1,1-trichloro-2,2-bis(4-methoxyphenol)-ethane (methoxychlor, MXC) can bind to estrogen receptors (ERs) and lead abnormality of ER depenent signaling pathways, resulting in human health problems such as dysfuction of reproduction and carcinogenesis. In this study, we investigated whethe...

ea0029p755 | Endocrine Disruptors | ICEECE2012

Benzophenone-1 promoted cell growth of BG-1 ovarian cancer cells with estrogen receptors via progression of cell cycle

Park M. , Lee H. , Jeung E. , Choi K.

Benzophenones are organic chemicals widely used as stabilizers to UV light irradiation in plastic surface coatings and food packaging. They have been known that their derivatives appear to have cytotoxic effects. 2-Hydroxy-4-methoxybenzophenone (Benzophenone-3, BP-3) and its metabolite, 2,4-dihydroxybenzophenone (Benzophenone-1, BP-1), are used mostly in the formulation of nail polishes, enamels, bath products, sunscreens and skin care products. In this study, the estrogenic e...

ea0029p946 | Female Reproduction | ICEECE2012

Inhibin-α gene promoter polymorphisms in patients with idiopathic premature ovarian failure

Yoon S. , Kim J. , Chae S. , Hwang K. , Choi Y\.

Background: Premature ovarian failure (POF) is a complex disorder defined as the cessation of ovarian function before or at the age of 40. Although the etiology of POF remains unknown in a large proportion of cases, it has been suggested that variations in the Inhibin α gene (INHA) may affect the ovarian function of women. This study was performed to investigate whether the genetic polymorphisms of the INHA gene are associated with idiopathic POF in a Korean population.</...