Endocrine Abstracts

Adrenal cortical carcinoma (ACC) is notorious for its aggressiveness and poor prognosis. A 71-year-old woman was found to be hypokalaemic with a serum potassium of 2.6 mmol/l [reference 3.6-5.0 mmol/l] on routine blood screening. Previous serum potassium readings were normal. She was asymptomatic and reported no gastro-intestinal losses. Her medical history was significant for hypertension, hyperlipidemia and hypothyroidism following total thyroidectomy for Graves’ Diseas...

Tumour-Induced Osteomalacia (TIO) is a rare paraneoplastic syndrome that is often underdiagnosed given its non-specific manifestations. A 64-year-old Chinese male presented with chest discomfort and generalized weakness. He was treated for symptomatic iron deficiency anaemia, with two units of blood transfusion given his low haemoglobin of 6.1 g/dl; no intravenous iron replacement was given. Concurrently, laboratory results revealed a low phosphate level of 0.4 mmol/l [referen...

Background: Severe hypercortisolism from ectopic adrenocorticotropic (ACTH) secretion may be life-threatening. The lung is the most common site of ACTH secreting tumours, ranging from bronchial carcinoids to small cell lung carcinoma. Olfactory neuroblastomas (ONB) are rare malignant neuroectodermal tumours. They show neuroendocrine differentiation and may exhibit a wide variety of paraneoplastic syndromes including ectopic ACTH secretion (EAS). We report a case of EAS from a ...