Searchable abstracts of presentations at key conferences in endocrinology

ea0021p315 | Reproduction | SFEBES2009

The role of thyroid hormone transporters MCT8 and MCT10 in the EVT-like cell line HTR8-SVneo

Choudhury Juhela , Loubiere Laurence , Vasilopoulou Elisavet , McCabe Christopher , Franklyn Jayne , Kilby Mark , Chan Shiao

Thyroid hormones (THs) are important for fetal and placental development. Monocarboxylate transporters 8 and 10 (MCT8 and MCT10) are effective plasma membrane TH transporters expressed in the human placenta from 6 weeks of gestation. Both have been localized to human villous trophoblasts and extravillous trophoblasts (EVTs).Aims: Using HTR-8/SVneo cells as a model of 1st trimester EVTs, we assessed 1) T3 effects on gene expression, cell prolif...