Searchable abstracts of presentations at key conferences in endocrinology

ea0044p88 | Clinical biochemistry | SFEBES2016

Prednisolone and fludrocortisone as once daily treatment following adrenalectomy

Papadopoulou Deborah , Choudhury Sirazum M , Meeran Karim

Mrs SP was a 50-year old patient who presented with typical features of Cushing’s syndrome in 2003 and proceeded to pituitary surgery. Following this she was not cured, and elected to have a bilateral adrenalectomy. Following this, she was initially commenced on hydrocortisone 30 mg daily taken as 15 mg in the morning, 10 mg at noon and 5 mg at 1600 h, and fludrocortisone 100 μg daily. She continued on this for 10 years, but switched her glucocorticoid replacement to...

ea0059p004 | Adrenal and steroids | SFEBES2018

Feasibility of immunological markers and osteocalcin as a barometer of glucocorticoid replacement

Ramadoss Vijay , Choudhury Sirazum M , Meeran Karim

Objective: To investigate a selection of novel bone or immunomarkers which may act as indicators for steroid replacement in Adrenal Insufficiency (AI).Introduction: AI is a condition where individuals are not able to produce sufficient steroids for their body’s requirement. Although mortality rates have improved since the introduction of exogenous steroid replacement, this condition is still associated with increased mortality and morbidity. This co...

ea0044p89 | Clinical biochemistry | SFEBES2016

The use of 8-h serum prednisolone concentrations to guide prednisolone dosing in replacement therapy

Papadopoulou Deborah , Choudhury Sirazum M , Meeran Karim , Wernig Florian

We here report the cases of two patients receiving glucocorticoid replacement, whose treatment has been guided by serum prednisolone measurements and whose day curves are presented below. Ms B was a 33-year-old patient who presented 3 years ago with panhypopituitarism following transsphenoidal surgery in 2012, for a sellar mass in a foreign country. She had already commenced 5mg prednisolone daily in addition to DDAVP, levothyroxine and the COCP. Having noticed mild weight gai...

ea0044p23 | Adrenal and Steroids | SFEBES2016

The pharmacokinetic profile of prednisolone is not affected by ingestion of food – how should patients be advised?

Choudhury Sirazum M , Williams Emma L , Tan Tricia M , Meeran Karim

Background: Prednisolone is used for glucocorticoid replacement therapy in Adrenal Insufficiency. Package inserts indicate that prednisolone should be administered with or after food as there is a belief that prednisolone causes stomach ulcers. We have investigated the impact of various fasted and non-fasted states on its pharmacokinetic profile.Method: A healthy volunteer provided three 4 mg prednisolone profiles. The first was a fasted reference curve....

ea0044p26 | Adrenal and Steroids | SFEBES2016

Could modified release prednisone hold the key to closer reproduction of the glucocorticoid circadian rhythm in Adrenal Insufficiency?

Choudhury Sirazum M , Leckey Adam , Williams Emma L , Tan Tricia M , Meeran Karim

Background: The cortisol circadian rhythm has an early morning peak with an increase before awakening, and a second lunchtime peak. Using a UPLC-MS/MS technique to measure prednisolone, the active metabolite of prednisone, we investigated the suitability of modified release (MR) prednisone (Lodotra) as a replacement therapy.Method: Blood samples were taken at fixed time points after the administration of MR-prednisone. Concentrations of the active metabo...