Searchable abstracts of presentations at key conferences in endocrinology

ea0022p66 | Adrenal | ECE2010

The HLA-DRB1 shared epitope and trans-encoded HLA-DQ-heterodimers hypothesis in autoimmune Addison disease

Pura Mikulas , Kuba Daniel , Kentos Peter , Chrenova Silvia , Vanuga Peter

Background: The MHC is the most important susceptibility locus for human autoimmune diseases (AID). Although associations between MHC class II DRB1 alleles and Addison disease (AD) have been repeteadly proven in various populations, the biological mechanisms underlying this association remains unknown. Peptide presentation to T cells may be important in the initiation or progression of AID. Disease-linked polymorphisms map to the peptide-binding sites of MHC molecules class II...