Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep728 | Pituitary: clinical | ECE2015

Impact of gsp mutations in somatotroph pituitary adenomas on growth hormone response to somatostatin analogues: a meta-analysis

Efstathiadou Zoe A , Bargiota Alexandra , Chrisoulidou Alexandra , Kanakis Georgios , Papanastasiou Lamprini , Theodoropoulou Anastasia , Tigas Stylianos K , Vassiliadi Dimitra , Alevizaki Maria , Tsagarakis Stylianos

Objective: Somatic mutations in the GNAS1 gene, which encodes the alpha-subunit of G stimulatory proteins (gsp), are frequently detected in somatotroph pituitary tumors and have been associated to specific clinical-smaller and less invasive tumors occurring in older patients- and histopathological-densely granulated adenomas- characteristics. However, the question whether the presence of a somatic gsp mutation affects the response to somatostatin analogue treatment remains unr...

ea0081ep142 | Calcium and Bone | ECE2022

Brown Tumors as a first sign of secondary hyperparathyroidism

Boudina Maria , Zouli Chrysanthi , Zisimopoulou Eleana , Fotiadou Aimilia , Stamati Mariana , Christantoniou George , Balodimou Chrysanthi , Chrisoulidou Alexandra

Aim: Brown tumors are a very rare and serious complication of sustained undiagnosed secondary hyperparathyroidism. Diagnosis and differential diagnosis are made by combining clinical, biochemical, radiological and pathological findings. We present the case of a male with chronic renal disease and multiple bone damage.A 58-year-old male was referred to the endocrine clinic because of lower back and pleural pain. He was an obese smoker with a heavy medical...

ea0035p606 | Endocrine tumours and neoplasia | ECE2014

Breast metastasis from medullary thyroid carcinoma in a man

Mandanas Stylianos , Margaritidou Efterpi , Georgopoulos Konstantinos , Boudina Maria , Chrisoulidou Alexandra , Pazaitou-Panayiotou Kalliopi

Introduction: Medullary thyroid carcinoma (MTC) originated from parafollicular C cells of the thyroid gland is a rare histological type of malignancy. Common sites of metastases are liver, lungs and bones, while metastases in other sites are extremely rare. Breast metastases from MTC are reported in 20 cases, and only in women.Case report: A 67-year-old man was presented after thyroidectomy for further evaluation and treatment. Histology was positive for...

ea0032p1091 | Thyroid cancer | ECE2013

Treating refractory thyroid cancer in the era of multitarget tyrosine kinase inhibitors

Mathiopoulou Lemonia , Boudina Maria , Chrisoulidou Alexandra , Mandanas Stylianos , Margaritidou Efterpi , Georgopoulos Konstantinos , Pazaitou-Panayiotou Kalliopi

Introduction: Tyrosine kinase inhibitors (sorafenib and sunitinib) have been used in treating refractory cases of thyroid cancer. The aim of our present study was to assess the efficacy of these agents in patients with refractory and progressive thyroid cancer, regarding patientsÂ’ quality of life, adverse events and response ratesPatients and methods: We retrospectively analyzed data of adult patients with differentiated and medullary thyroid cancer...

ea0041ep874 | Pituitary - Clinical | ECE2016

Discrepant GH and IGF-I values in the evaluation of treated acromegalic patients; an ongoing challenge. A meta-analysis

Kanakis George , Chrisoulidou Alexandra , Bargiota Alexandra , Efstathiadou Zoe , Papanastasiou Lamprini , Theodoropoulou Anastasia , Tigas Stylianos , Vassiliadi Dimitra , Tsagarakis Stylianos , Alevizaki Maria

Purpose: Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-I) are currently the principal biomarkers used to assess disease activity in acromegaly and any discrepancy between them renders interpretation of results inconclusive. The purpose of this study was to assess the frequency of discrepant results and identify parameters that might affect the emergence of this phenomenon.Methods: A systematic review of Medline and Scopus was performed (1987&...

ea0032p75 | Bone and Osteoporosis | ECE2013

Calcium homeostasis in women with non-metastatic breast cancer with osteoporosis after a single-dose of denosumab: a pilot study

Mandanas Stylianos , Toulis Konstantinos , Mathiopoulou Lemonia , Margaritidou Efterpi , Georgopoulos Konstantinos , Boudina Maria , Chrisoulidou Alexandra , Pazaitou-Panayiotou Kalliopi

Introduction: Women with non-metastatic breast cancer form a distinct subpopulation in which calcium homeostasis in response to treatment with denosumab has not been extensively investigated.Methods: Female patients with osteoporosis, who were eligible for treatment with denosumab, were prospectively enrolled (2011–2012) and divided into two groups; Group A consisting of patients with either no history or benign diseases non affecting bone metabolis...

ea0073ep35 | Calcium and Bone | ECE2021

Coexistence of multiple cystic parathyroid adenomas and thyroid carcinoma

Boudina Maria , Syndouka Eleni , Fotiadou Aimilia , Stamati Mariana , Zouli Chrysanthi , Argyropoulou Elpiniki , Theodosios S. Papavramidis , Chrisoulidou Alexandra

BackgroundCystic parathyroid adenoma is a rare entity (<0.01% of all cervical masses) that leads to primary hyperparathyroidism in 9% of cases. Parathyroid scintigraphy is essential for the diagnosis although there are pitfalls with false negative results. Parathyroidectomy is the treatment of choice but its success depends on the exact preoperative localization of the parathyroid lesions. 4D-CT is a very helpful diagnostic tool in such cases.<p ...

ea0063p833 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

The role of somatostatin analogs in the control of carcinoid syndrome: systematic review and meta-analysis

Alexandraki Krystallenia , Angelousi Anna , Chatzellis Eleftherios , Chrisoulidou Alexandra , Kalogeris Nikolaos , Kanakis Georgios , Savvidis Christos , Vassiliadi Dimitra , Toulis Konstantinos , Tsagarakis Stylianos , Kaltsas Gregory

Introduction: Somatostatin analogues (SSAs) are the mainstay of treatment for carcinoid syndrome (CS)-related symptoms. Controversy still exists regarding the extent of the efficacy of this intervention. The purpose of the systematic review and meta-analysis was to evaluate the percentage of patients achieving partial (PR) or complete response (CR) with the use of SSAs (lanreotide, octreotide, pasireotide) in patients with CS. Due to lack of uniformity and established criteria...