Searchable abstracts of presentations at key conferences in endocrinology

ea0063s14.1 | Innovations in NETs | ECE2019

Innovative imaging of benign insulinomas – the end of sampling

Christ Emanuel

Background: Benign insulinomas are the most prevalent cause of endogenous hyperinsulinaemic hypoglycaemia (EHH) in adults and due to their small size difficult to localise. Until now, the most sensitive test to localize the area of the potential insulinoma was the intra-arterial calcium stimulation test, an invasive procedure with its associated risk. In contrast to the other neuroendocrine tumors, benign insulinomas do not exhibit upregulated somatostatin receptors sutype 2 (...

ea0063gp257 | Thyroid Nodules and Cancer 2 | ECE2019

Effects of hospital volume on clinical outcomes after thyroidectomy - a Swiss nation-wide study

Ebrahimi Fahim , Kutz Alexander , Christ Emanuel , Schuetz Philipp , Mueller Beat

Background: Epidemiologocal data suggest an continuous increase in thyroid carcinoma diagnosis. Therefore, thyroidectomy rates are projected to increase world-wide in exponential scale. In Switzerland, the institutional number of thyroidectomies varies, however there is no data yet on the association between institutional thyroidectomy volume and clinical outcome.Methods: Cross-sectional analysis of adult inpatients in Swiss hospitals using a nation-wide...

ea0063p797 | Thyroid 2 | ECE2019

Gender-specific variations of clinical outcomes after thyroidectomy

Kutz Alexander , Ebrahimi Fahim , Christ Emanuel , Schuetz Philipp , Mueller Beat

Background: Incidence of thyroidectomies and awareness to postoperative quality measures have both increased in the last decade. Gender-specific indications and variations in clinical outcomes of patients undergoing thyroidectomy in Switzerland are of interest.Methods: We cross-sectionally compared administrative nationwide patient-level data for length of hospital stay (LOS), intensive care unit (ICU) admission, 30-day readmissions rates, and other qual...

ea0070ep99 | Bone and Calcium | ECE2020

Idiopathic Hypoparathyroidism – An uncommon cause of a chest pain

Zechmann Stefan , Felder Susan , Christ Emanuel , Potlukova Eliska

Introduction: Hypocalcemia has been linked to a decreased myocardial performance and even congestive heart failure, while acute chest-pain as leading symptom of hypocalcemia is an unusual presentation.Case report: A 29-year-old Caucasian man presented to the emergency department with relapsing chest-pain since several days, lasting seconds sometimes lasting several minutes, radiating to the left shoulder and combined with mild tingling in the neck. A det...

ea0032p886 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Short-term exercise-induced GH response in athletes: differential results for runners and bikers when tested on bicycle

Zueger Thomas , Bucher Julie , Christ Emanuel , Stettler Christoph

Background/introduction: SUB:Pituitary – Clinical (Generously supported by IPSEN)We have previously shown that GH assessment during a standardized aerobic exercise of moderate intensity is a reliable test with high diagnostic accuracy in predicting severe GH deficiency (GHD) in adult individuals. However, these studies comprised comparably long exercise durations around 60 min or longer. To improve clinical applicability of exercise testing in the diagnosis of GH...

ea0014p32 | (1) | ECE2007

Effects of rosiglitazone (RGZ) and pioglitazone (PGZ) on serum androgens and urinary steroid profile in patients with type 2 diabetes: A prospective, randomised cross-over study

Chappuis Bernard , Braun Monika , Stettler Christoph , Diem Peter , Christ Emanuel

Background: Glitazones (GZ) influence androgen biosynthesis in PCO syndrome. At present it is unknown whether a) steroid hormone metabolism is influenced by GZ in patients with type 2 diabetes b) there is a differential effect of RGZ and PGZ on steroid hormone metabolism c) this effect is sex-specific and d) this effect is mediated by changes in insulin sensitivity. Therefore, urinary steroid profiles and serum total testosterone and DHEA levels were analysed before and after ...

ea0049ep986 | Pituitary - Clinical | ECE2017

Long-term impact of primary medical and surgical therapy on bone density in men versus women with prolactinomas

Andereggen Lukas , Frey Janine , Andres Robert , El-Koussy Marwan , Beck Jurgen , Mariani Luigi , Christ Emanuel

Purpose: The prevalence of pathological bone densities in men and women with prolactinomas treated either primary surgically or medically are infrequently reported across large cohorts. In the present study, we aimed at comparing the impact of either therapeutic approach on the bone density in men vs women with prolactinomas.Methods: Retrospective case-note study including all consecutive patients with prolactinomas in whom osteodensitometry data was ava...

ea0041gp53 | Cardiovascular endocrinology | ECE2016

Different repletion of intramyocellular lipid (IMCL) in patients with growth hormone deficiency (GHD) compared to control subjects (CS) 24 h after a 2-h aerobic exercise

Jenni Stefan , Loher Hannah , Bucher Julie , Ith Michael , Boesch Chris , Kreis Roland , Christ Emanuel R

Background: We and others have shown that ectopic lipids are flexible fuel stores in healthy subjects, in patients with type 1 diabetes or with GHD. IMCL are depleted by exercise and repleted by diet, whereas intrahepatocellular lipids (IHCL) are increased immediately after exercise. It is unclear whether the exercise-induced flexibility of IMCL and IHCL persists until 24 h and whether healthy subjects and patients with GHD behave differently.Methods: Ma...

ea0037ep1115 | Endocrine tumours | ECE2015

Multifocal insulinomas (insulinomatosis) in GLP-1-receptor PET/CT

Jenni Stefan , Antwi Kwadwo , Fani Melponemi , Wild Damian , Heye Tobias , Gloor Beat , Perren Aurel , Christ Emanuel

Introduction: Apart from occurring sporadically, insulinoma within the framework of multiple endocrine neoplasia 1 (MEN-1) is well known. The rare presence of multifocal insulinomas has recently been assigned a separate entity (insulinomatosis). The difficulty of localising insulinomas may be improved by GLP1-receptor imaging.Case report A 48-year-old woman had been treated for suspected epileptic seizures for 2 years (lamotrigine). During another such e...

ea0070aep743 | Pituitary and Neuroendocrinology | ECE2020

Central hypothyroidism as an adverse effect of bexarotene treatment for cutaneous T-cell lymphoma

Felder Susan , Zechmann Stefan , Baur Katharina , Seelig Eleonora , Christ Emanuel , Holbro Andreas , Potlukova Eliska

Introduction: Central hypothyroidism is rare, estimated to occur in 1:20,000 to 1:80,000 in the general population. Pituitary mass lesions and adverse effects of their treatment are the most common causes of central hypothyroidism. In recent years, the incidence of pituitary hormonal deficiencies as adverse effects of novel molecular targeting anticancer drugs has risen sharply. Especially checkpoint inhibitors are associated with partial or complete hypopituitarism. In this r...