Searchable abstracts of presentations at key conferences in endocrinology

ea0052nets2 | Speaker Abstracts | UKINETS2017

The role of pathology and the new WHO classification

Christian Adam

Neuroendocrine tumours have a number of different classification and staging systems. I will present the latest of these, which include the latest WHO system with the implications for new entities and how they are diagnosed pathologically and any difficulties that arise from this. There will also be a more general discussion about areas that are difficult for the pathologist and where we can add value to the MDT discussion....

ea0049s28.1 | Sleep, love and reproduction (Endorsed by Endocrine Connections) | ECE2017

Candidate mechanisms underlying the association between poor sleep and obesity

Benedict Christian

An increasing proportion of people living in our 24/7 culture complain about insomnia symptoms, i.e., they experience problems to fall and/or stay asleep. As demonstrated by epidemiological studies, chronic sleep loss is correlated with weight gain. To investigate whether sleep loss would alter energy metabolism in favour of weight gain, my lab therefore performed a series of sleep loss experiments in metabolically healthy normal-weight subjects. These studies demonstrated tha...

ea0038mte1 | (1) | SFEBES2015

Cutting edge imaging of whole endocrine organs

Christian Helen

Recent advances in tridimensional (3D) tissue imaging and development of reporter proteins have provided new insight into the dynamic relationship between tissue structure, function and dysfunction in a number of fields of research. In developmental biology 3D microscopy has enabled building of quantitative 3D atlases of embryo morphology and gene expression at cellular resolution and in neuroscience ‘connectomics’, the building of 3D brain connectivity maps is a rap...

ea0020s25.3 | Pathophysiology and treatment of Type 2 Diabetes | ECE2009

FTO and obesity

Dina Christian

Three independent studies identified SNPs in the first intron of the gene FTO as being strongly and consistently associated with BMI and/or obesity at significance levels (P=10−7 to P=10−30) unobserved so far in genetics of obesity. The three studies estimated the putative effect around 1% of the total variance of BMI. So far, this represents the strongest effect for a common variant in obesity.This result ...

ea0015s16 | System-specific effect steroids | SFEBES2008

Glucocorticoids, folliculostellate cells and the pituitary

Christian Helen

Glucocorticoids act within the pituitary gland to maintain the blood levels of glucocorticoids within appropriate limits by negative feedback on the secretion of corticotrophin (ACTH). Annexin 1 (ANXA1) is a calcium- and phospholipid binding protein which was originally identified as a mediator of the anti-inflammatory actions of glucocorticoids in the host defence system. Subsequent work has shown that it that plays an important role in the early delayed (30 min-3 h) feedback...

ea0063mtbs1 | (1) | ECE2019

New tracers for PET in humans: Hopes, aims and current evidence

Gormsen Lars Christian

Positron emission tomography (PET) using the glucose analog tracer fluoro-deoxy-glucose (FDG) is today a widely available and highly useful functional imaging modality. Thus, FDG-PET has proved its clinical worth in particularly malignancy detection and treatment monitoring and is now often a first-line choice in the diagnostics of a range of diseases. However, PET is also an excellent tool for non-invasive measurement of metabolic processes, pathophysiology and pharmacokineti...

ea0034p282 | Pituitary | SFEBES2014

Lack of Fpr2/Fpr3 receptors alters the structure and function of pituitary corticotrophs

Mahmood Maria , Christian Helen

Introduction: The N-formyl peptide receptor (FPR) family of G-protein-coupled receptors, originally identified to recognise N-formylated bacterial peptides, has in more recent times been shown to bind annexin-1 (ANXA1). ANXA1 is a signalling molecule well demonstrated to mediate two key glucocorticoid effects in the anterior pituitary: inhibition of ACTH release from corticotrophs and regulation of cell proliferation. Whilst previous RT-PCR studies have detec...

ea0031p244 | Pituitary | SFEBES2013

Secretory granule accumulation in anterior pituitary somatotrophs of TPC1 null mice

Gannon Sarah , Christian Helen

Calcium mobilization from intracellular stores represents an important cell signalling process that is regulated, in mammalian cells, by inositol-1,4,5-triphosphate (IP3), cyclic ADP ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP). Intracellular calcium is important for mobilization of secretory granules to the plasma membrane in preparation for exocytosis. NAADP mobilizes calcium from lysosome-related acidic compartments and it has been sho...

ea0044p164 | Neuroendocrinology and pituitary | SFEBES2016

Investigation of the appearance of adenohypophyseal folliculostellate cells during embryonic chick development

Talintyre Iona , Begbie Jo , Christian Helen

Folliculostellate (FS) cells constitute around 10% of the adenohypophyseal cell population. Various functions of these non-endocrine cells have been elucidated, including the paracrine control of the function of local endocrine cells. FS cell development is currently very poorly understood. In this study FS cell appearance during embryonic chick development between pre-natal stages (st)17-37 was examined. Gene and protein expression of the FS marker proteins annexin A1 (AnxA1)...

ea0059p148 | Neuroendocrinology and pituitary | SFEBES2018

Investigation of gonadotroph ultrastructure secretory machinery in a novel mouse model of Patched1 deletion in folliculostellate cells

Chan Joyce , Ren Yi , Christian Helen

The sonic hedgehog (shh) pathway is known to be essential for pituitary development but little is known of its role in adult pituitary. Patched1, encoded by the Patched1 (Ptch1) gene, is a receptor for shh expressed in all cell types of the anterior pituitary. Adult onset hypogonadotropic hypogonadism has been reported in a genetically engineered mouse line with deletion of Ptch1 using S100a4 promoter driven CRE recombinase expression which is restri...