Searchable abstracts of presentations at key conferences in endocrinology

ea0049oc1.4 | Adrenal-Basic & Clinical | ECE2017

The epidemiology of pheochromocytoma: increasing incidence and changing clinical presentation. A population-based retrospective study 1977–2015

Ebbehoj Andreas Ladefoged , Sondergaard Esben , Trolle Christian , Stochholm Kirstine , Poulsen Per Logstrup

Pheochromocytoma is a rare disease but frequently poses a diagnostic dilemma due to the unspecific symptoms and its potentially life-threatening nature. There is a perception of an increase in the incidence of pheocromocytomas in recent years, but no data on time trends exist. We obtained data from The Danish National Registry of Patients, The Danish Registry of Causes of Death, and The National Pathology Registry for all persons registered with pheochromocytoma in 1977–2...

ea0032p22 | Adrenal cortex | ECE2013

21-hydroxylase and interferon omega autoantibodies in Turner syndrome

Cleemann Line , Oftedal Bergithe , Trolle Christian , Holm Kirsten , Husebye Eystein , Gravholt Claus

Introduction: An increased frequency of autoimmune diseases and an elevated incidence of autoantibodies have been observed in Turner syndrome (TS), but indirect immunofluorescence (IIF) has not been able to demonstrate autoantibodies against the adrenal cortex. We asked if the more sensitive radioimmunosorbant assay employing recombinant human 21-hydroxylase was able to identify autoantibodies against 21-hydroxylase, (21OH-Ab) in TS patients; 21-hydroxylase is the major adrena...

ea0032p196 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Perturbed sympatho-vagal balance in Turner syndrome: relation to phenotype and aortic dilation

Trolle Christian , Mortensen Kristian Havmand , Hjerrild Britta , Andersen Niels Holmark , Gravholt Claus Hojbjerg

Objective: The risk of aortic dissection is 100-fold increased in Turner syndrome (TS). Increased blood pressure (BP) and heart rate is present as well as an increased risk of ischemic heart disease and diabetes. This study aimed to prospectively assess heart rate variability (HRV) in TS and its relation to aortic dimensions.Methods: Adults with TS (n=91, aged 37.4±10.4 years) recruited through the Danish National Society of Turner Syndrome...

ea0032p176 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Long QT interval in Turner syndrome: a high prevalence of LQTS gene mutations

Trolle Christian , Mortensen Kristian Havmand , Pedersen Lisbeth Norum , Jensen Henrik Kjaerulf , Andersen Niels Holmark , Gravholt Claus Hojbjerg

Objective: QT interval prolongation of unknown aetiology is common in Turner syndrome (TS). This study set out to explore the presence of known pathogenic long QT (LQT) mutations in TS and to examine the corrected QT interval (QTc) over time and relate the findings to the TS phenotype.Methods: Adult females with TS (n=102) were examined thrice with a mean follow-up of 4.7±0.5 years, and 68 age-matched healthy controls were examined once. QT...

ea0056gp44 | Adrenal medulla and NETs | ECE2018

Mortality in patients with Pheochromocytoma: a population-based study 1977–2016

Ebbehoj Andreas Ladefoged , Sondergaard Esben , Jacobsen Sarah Forslund , Trolle Christian , Robaczyk Maciej Grzegorz , Rasmussen AEse Krogh , Feldt-Rasmussen Ulla , Thomsen Reimar Wernich , Stochholm Kirstine , Poulsen Per Logstrup

Background: Pheochromocytomas and catecholamine-secreting paragangliomas (PPGL) are rare catecholamine-producing tumors. Due to the rarity, limited data on prognosis exists and data are mainly from tertiary centers with potential referral bias. Here, we present population-based mortality data over an observation period of 40 years.Materials and methods: We identified a cohort of 198 PPGL patients diagnosed 1 January 1977 to 31 December 2016 in North and ...