Searchable abstracts of presentations at key conferences in endocrinology

ea0031oc5.1 | Pituitary and neoplasia | SFEBES2013

Genetic background influences tumour phenotype in heterozygous Men1 knockout mice

Lines Kate E , Javid Mahsa , Reed Anita A C , Piret Sian E , Walls Gerard V , Stevenson Mark , Christie Paul T , Thakker Rajesh V

Multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disorder characterised by the occurrence of parathyroid, pancreatic islet and anterior pituitary tumours, is due to mutations of a tumour suppressor gene, MEN1. MEN1 mutations have also been reported to cause familial isolated primary hyperparathyroidism (FIHP). Moreover, 15 identical MEN1 mutations have been reported to cause MEN1 or FIHP in unrelated families; thereby implicating a r...