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Premature ovarian failure or primary ovarian insufficiency (POI) is characterized by amenorrhea occurring before the age of 40-year-old, with elevated gonadotropins (FSH >20 mIU/ml). It affects 12% of women. So far, in more than 75% of cases, its etiology remains unknown.The obvious causes are chemotherapy, radiotherapy and ovarian surgery, mainly for bilateral ovarian endometriomas. Genetic causes of POI include rare diseases, such as blepharo...

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ea0014s18.3 | Puberty and hypogonadism | ECE2007

Clinical management of premature ovarian failure

Christin-Maitre S

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ea0029oc13.3 | Adrenal Basic | ICEECE2012

Cortisol secretion is dependent on intraadrenal production of ACTH in macronodular bilateral adrenal hyperplasia causing Cushings syndrome

Louiset E. , Duparc C. , Young J. , Boutelet I. , Renouf S. , Bram Z. , Groussin L. , Caron P. , Tabarin A. , Grunenberger F. , Christin-Maitre S. , Kuhn J. , Anouar Y. , Bertherat J. , Lefebvre H.

Illicit expression of membrane receptors for circulating regulatory factors, such as gastric inhibitory polypeptide (GIP), luteinizing hormone (LH) and serotonin (5-HT) receptors, has been well documented in ACTH-independent macronodular adrenal hyperplasias (AIMAHs) causing Cushings syndrome. In addition, we have observed an abnormal expression of ACTH in some steroidogenic cells in two AIMAH tissues. The aim of the present study was to investigate the role of local pro...

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ea0029p993 | Growth hormone IGF axis - basic | ICEECE2012

Clinical characteristics and outcome of acromegaly induced by ectopic secretion of GHRH: a French nationwide series of 21 cases

Garby L. , Caron P. , Claustrat F. , Chanson P. , Tabarin A. , Rohmer V. , Arnault G. , Bonnet F. , Chabre O. , Christin Maitre S. , Du Boullay H. , Murat A. , Nakib I. , Sadoul J. , Sassolas G. , Claustrat B. , Raverot G. , Borson Chazot F.

Context: Ectopic GHRH secretion is a rare cause of acromegaly described mainly in isolated case reports.Setting: From the registry of the sole laboratory performing plasma GHRH assays in France, we identified cases of ectopic GHRH secretion presenting with acromegaly between 1983 and 2008.Patients: In total, 21 patients aged 1477 years, from 12 French hospitals. Median GHRH was 548 ng/l (2709779)....

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ea0014oc6.4 | Cardiovascular endocrinology | ECE2007

Carotid IMT and stiffness, aortic stiffness and pulse pressure: association with hormone therapy in postmenopausal women: baseline findings from the CASHMERE trial

Simon T , Boutouyrie P , Christin-Maitre S , Gompel A , Joanides R , Kearny-Schwartz A , Kuntz Ch , Laurent S , Pannier B , Pornel B , Struijker-Boudier HH , Thuilliez Ch , Van Bortel L , Zannad F , Pithois-Merli I , Jaillon P

Common carotid artery intima media thickness (CCA-IMT), aortic stiffness (carotid-femoral pulse wave velocity-PWV) and central pulse pressure (PP) are early markers of atherosclerosis. The influence of hormonal replacement treatment (HRT) on arterial parameters in menopausal women remains to be investigated.We used baseline data of 665 menopausal women with hypercholesterolemia, screened for the CASHMERE study, a 12-month double-blind randomized trial co...

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ea0014p49 | (1) | ECE2007

Deleterious effects of beta-blockers on arterial stiffness and central pulse pressure in menopausal women: baseline findings from the Cashmere trial

Laurent S , Christin Maitre S , Gompel A , Boutouyrie P , Jaillon P , Thuilliez Ch , Zannad F , Pornel B , Pannier B , Struijker-Boudier H , Van Bortel L , Kuntz Ch , Keanry-Schwartz A , Pithois-Merli I , Simonneau D , Simon T

Beta-blockers (BB) may be less effective than other antihypertensive drugs for stroke prevention in patients with primary hypertension (ASCOT and LIFE studies). Our study compares arterial stiffness and central PP between users (BB+) and non users of BB (BB-), among menopausal women with hypercholesterolemia and no history of CV disease.Methods and Results: We used the baseline data of 664 menopausal women, screened for the Cashmere study, a12-month doub...

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Endocrine Abstracts

Premature ovarian insufficiency

Clinical management of premature ovarian failure

Cortisol secretion is dependent on intraadrenal production of ACTH in macronodular bilateral adrenal hyperplasia causing Cushings syndrome

Clinical characteristics and outcome of acromegaly induced by ectopic secretion of GHRH: a French nationwide series of 21 cases

Carotid IMT and stiffness, aortic stiffness and pulse pressure: association with hormone therapy in postmenopausal women: baseline findings from the CASHMERE trial

Deleterious effects of beta-blockers on arterial stiffness and central pulse pressure in menopausal women: baseline findings from the Cashmere trial

BiosciAbstracts