Searchable abstracts of presentations at key conferences in endocrinology

ea0095oc6.5 | Oral Communications 6 | BSPED2023

Growth hormone excess in children with pituitary adenomas associated with endocrine syndromes

Park Julie , Daousi Christina , Blair Joanne

Growth hormone (GH) excess is extremely rare in children. It can be associated with endocrine syndromes including MEN1, Carney complex and Mc Cune Albright syndrome. We describe two cases of GH excess and their management. Patient A (15yr M) presented with fibrous dysplasia affecting his cranium and a large café-au-lait spot covering his right scapula. His height was 193cm (2.6 SDS) and BMI 29.6kg/m2(2.3SDS). His IGF1 was 84.1nmol/L (22.5 – 65.9) and GH did not suppr...

ea0021p272 | Pituitary | SFEBES2009

Obesity and cardiovascular risk factors in adult patients with acquired structural hypothalamic damage

Steele Caroline , MacFarlane Ian , Javadpour Mohsen , Daousi Christina

Background: Obesity is a common sequel to tumours of the hypothalamic region and their treatment. Weight gain occurs at a rate faster than any expected age-related increase and despite treated hormone deficiencies.Methods: Retrospective review of patients with hypothalamic-pituitary tumours attending a large neuroendocrine clinic in UK.Results: Initial review in 2002 had identified 42 adults with tumours causing hypothalamic damage...

ea0062p50 | Poster Presentations | EU2019

Nature’s price for Cushing’s disease: A blind eye and a hole in the (pituitary) Middle

Sullivan Heather , Westall Sam , McNulty Sid , Furlong Niall , Gilkes Catherine , Daousi Christina , Narayanan Prakash

Case history: A 61 year old male with a background of diabetes mellitus Type 2 and congestive cardiac failure (CCF) was diagnosed with Cushing’s disease in 2014 following identification of severe osteoporosis through investigations for non-traumatic vertebral fractures causing paraplegia.Investigations: He had high ACTH and cortisol levels which failed to suppress on low and high dose dexamethasone suppression tests, hypogonadotrophic hypogonadism a...

ea0059ep53 | Clinical practice, governance & case reports | SFEBES2018

Case Report: The experience of using Etomidate in the management of severe Cushing’s disease and MRSA bacteraemia in a district general hospital in the United Kingdom

Wong Stephanie , Yap Yew Wen , Narayanan Prakash , Daousi Christina , Al-Jubouri Mohammad , Mahgoub Yahya

Background: The management of Cushing’s disease can be challenging especially when patients can present with sepsis and severely immunocompromised with limited oral medications to achieve cortisol control. We review a case of Cushing’s disease and the medical management of Cushing’s disease.Case Report: A 54 year old female presented with symptomatic hyperglycaemia with truncal obesity, proximal muscle weakness, right posterior thorax haem...

ea0028p29 | Clinical biochemistry | SFEBES2012

The incidence, and impact on outcome, of hypo- and hypernatraemia in patients with spontaneous aneurysmal subarachnoid haemorrhage (SAH)

Daousi Christina , Gill Geoffrey , Cooper Shirley , Stoneley Catherine , Eldridge Paul , Javadpour Mohsen , Cuthbertson Daniel

Aims: To ascertain the incidence of hypo- and hyper-natraemia in patients admitted to a tertiary neurosurgical centre with confirmed spontaneous aneurysmal subarachnoid haemorrhage (SAH), and to determine their impact on length of hospital stay and mortality.Methods: Retrospective case note review of patients admitted between January 2008 and April 2011.Results: 402 patients with SAH were identified [mean (±sd</sma...

ea0028p254 | Pituitary | SFEBES2012

The Pituitary Apoplexy Score (PAS) in the evaluation and management of acute pituitary apoplexy: a single centre experience from the United Kingdom

Thondam Sravan , Bujawansa Sumudu , Noonan Carmel , MacFarlane Ian , Javadpour Mohsen , Daousi Christina

Aims: The United Kingdom (UK) guidelines for management of acute pituitary apoplexy recommend the Pituitary Apoplexy Score (PAS) to objectively assess clinical severity of this rare neuro-endocrine emergency. We aimed to apply retrospectively this scoring tool to a large, single centre series of patients with acute pituitary apoplexy, and to determine its applicability in the management of these patients in the acute setting.Methods: Retrospective study ...

ea0025p150 | Diabetes, metabolism and cardiovascular | SFEBES2011

The prevalence of non alcoholic fatty liver disease in GH deficiency and the effect of GH replacement

Gardner Chris , Irwin Andrew , Joseph Francis , Wong Chris , Adams Val , Daousi Christina , Kemp Graham , Cuthbertson Daniel

Background: Non-alcoholic fatty liver disease (NAFLD) is reported to be more prevalent in patients with GH deficiency (GHD) than in the general population. Case control studies have not however been undertaken. Recognition of NAFLD is important due to its association with cardiovascular disease and chronic liver disease.Aims: To determine i) the prevalence of NAFLD in patients with severe GHD compared to age and BMI-matched controls, and, ii) the effect ...

ea0023oc4.3 | Oral Communications 4 | BSPED2009

Pituitary adenomas presenting in children and young people: a single centre experience

Steele Caroline , Blair Jo , Didi Mo , Javadpour Mohsen , MacFarlane Ian , Daousi Christina

Introduction: Pituitary adenomas are uncommon in childhood and adolescence and knowledge of long-term outcomes is sparse. We describe a large cohort of patients, now attending our adult clinic.Patients and methods: Retrospective review of patients aged ≤18 years at diagnosis of a pituitary adenoma.Results: There were 24 patients (18 female), mean age at diagnosis 15.6 (range 11–18) years, current age 25.5 (14–47). O...

ea0021p283 | Pituitary | SFEBES2009

Presentation, management and outcomes in acute pituitary apoplexy: a single centre experience from the United Kingdom

Bleaney William , MacFarlane Ian , Rothwell Nicola , Noonan Carmel , Javadpour Mohsen , Daousi Christina

Background: Pituitary apoplexy is rare resulting from acute haemorrhagic infarction of a pituitary adenoma. Optimal management in the acute stage still remains a matter of debate.Methods: Retrospective analysis of casenotes of patients presenting with acute apoplexy at a single neurosurgical centre between 1984 and 2009 in the United Kingdom.Results: Fifty-five patients (35 males, mean age 52.4 (range 14–78) years, mean years ...

ea0066oc2.1 | Oral Communications 2 | BSPED2019

National United Kingdom evidence- and consensus-based guidelines for the investigation, treatment and long-term follow-up of paediatric craniopharyngioma

Gan Hoong-Wei , Morillon Paul , Albanese Assunta , Aquilina Kristian , Barkas Konstantinos , Chandler Chris , Chang Yen-Ch'ng , Daousi Christina , Drimtzias Evangelos , Farndon Sarah , Jacques Tom , Korbonits Marta , Kuczynski Adam , Limond Jennifer , Robinson Louise , Simmons Ian , Thomas Nick , Thomas Sophie , Thorpe Nicola , Vargha-Khadem Faraneh , Warren Daniel , Zebian Bassel , Gamble Ashley , Wilne Sophie , Harrison Barney , Spoudeas Helen , Mallucci Conor

Aims: Although rare, craniopharyngiomas are the commonest suprasellar tumour in childhood. Despite high overall survival, children and young people <19 years with craniopharyngiomas are at risk of multiple relapses and long-term tumour- and treatment-related morbidity. We sought to provide, for the first time, a national standard for best practice based on currently available evidence for the assessment, treatment and follow-up of paediatric craniopharyngiomas under the au...