Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep1080 | Late Breaking | ECE2023

Gitelman syndrome, a rare disease: case report

Dumitru Teodora , Preda Cristina , Rosu Andreea , Akad Nada , Anisia Miruna , Leustean Letitia , Christina Ungureanu Maria

Introduction: Gitelman syndrome(GS) is a salt-wasting tubulopathy characterized by renal potassium wasting, hypokalemia, metabolic alkalosis, hypomagnesemia, hypocalciuria and hyperreninemic hyperaldosteronism. It is caused by the mutation of genes encoding sodium chloride (NCCT) and magnesium transporters in the thiazide-sensitive segments of the distal nephron (SLC12A3 and TRMP6 gene). GS is a rare autosomal recessive disease with a prevalence of only 25 cases per one millio...

ea0090ep1142 | Late Breaking | ECE2023

The underneaths of the pituitary stalk

Christina Ungureanu Maria , Preda Cristina , Akad Nada , Dumitru Teodora , Karolina-Agatha Drozdek

We are presenting a 23-year-old girl with a medical history of juvenile rheumatoid polyarthritis treated with methotrexate, that first addressed to the Endocrinology Department in may 2022 for primary amenorrhoea with poorly developed secondary sexual characters: height 160 cm, weight 48 kg, BMI 18.35 kg/m2, Tanner stages P1, B3. She was treated with oral contraceptives by the gynaecologist in the past without a hormonal assessment. The lab work revealed hypogonadotropic hypog...

ea0090ep1146 | Late Breaking | ECE2023

Normal adult height in a pacient with untreated congenital hypopituitarism: a case report

Bilha Stefana , Popa Viviana , Teodoriu Laura , Christina Ungureanu Maria , Preda Cristina

With congenital hypopituitarism, the clinical manifestations of pituitary hormone deficiencies usually appear during infancy or early childhood. Typically, one or more anterior pituitary hormones are deficient, and the most severe manifestations include neonatal hypoglycemia, electrolyte imbalances and failure to thrive. We present the case of a 43 year old male, with cardiovascular and metabolic comorbidities (arterial hypertension, type 2 diabetes mellitus), with no prior ho...

ea0090ep1148 | Late Breaking | ECE2023

Major improvement of diabetes insipidus 15 years after diagnosis of panhypopituitarism in a patient with pineal germinoma – a case report

Popa Viviana , Rosu Andreea , Crumpei Iulia , Christina Ungureanu Maria , Preda Cristina

Pineal germinomas account for the majority of intracranial germ cell tumors. Surgery and radiation are usual management options, and secondary hypopituitarism can ensue after both. Diabetes insipidus is particularly common after surgical removal of pineal tumors, but improvement in polyuria and polydipsia years after surgery is exceedingly rare. Here, we present the case of a 49-year-old male, who was diagnosed with a pineal germinoma at the age of 20, which was surgically rem...

ea0063p1084 | Pituitary and Neuroendocrinology 3 | ECE2019

Case report: polynodular goiter and pituitary macroadenoma co-secreting growth hormone and thyroid stimulating hormone

Maria Hrisca Ana , Christina Ungureanu Maria , Chiriac Anca E. , Potorac Iulia

Purpose: The purpose is to draw attention to rare cases of Pituitary Macroadenoma co-secreting Growth Hormone and Thyroid Stimulating Hormone with Polynodular Goiter and their importance and approach in current practice.Background: Pituitary adenomas with no hormonal clinical picture are known as ‘silent’ tumors. They are rarely reported and lacking pathogenic explanations.Method: We describe a case of Pituitary Macroaden...

ea0070ep441 | Thyroid | ECE2020

Management difficulties in nodular goiter associated with hypopharynx infiltration – case report

Teodoriu Laura , Magdalena Boboc Andreea , Neagu Georgiana , Ioan Bianca , Rosu Andreea , Christina Ungureanu Maria , Preda Cristina

Introduction: The connection between the pharynx and thyroid is close, so in the situations of concomitance: thyroid nodules and pharynx infiltration is very difficult to establish the primary lesion. Extralaryngeal spread of laryngopharyngeal cancer to the thyroid gland can occur by three pathways: direct extension, lymphatic spread or hematogenous spread. Of these three mechanisms, direct extension is the main mechanism because of the close anatomical relationship of the thy...

ea0070ep487 | Thyroid | ECE2020

The association between thyroid anaplastic carcinoma and papilar carcinoma folicular version – longer life expectancy?

Nechita Mirela-Claudia , Tudurean-Olteanu Anca-Georgiana , Dumitru Teodora , Florescu Alexandru , Christina Ungureanu Maria

Introduction: Anaplastic thyroid carcinoma are highly aggressive solid tumors, with a median survival of less than 6 months after diagnosis. They typically occur in patients who are 65 years of age or older. On the other hand, papillary thyroid carcinoma and follicular thyroid carcinoma are generally indolent, with very few progressive cases.Case report: A 64-year-old patient with no significant pathological history, known with goiter for about 40 years ...

ea0032p631 | Growth hormome IGF axis – basic | ECE2013

GH therapy in Turner syndrome: growth rate indirectly correlated with age of therapy initiation

Hristov Ioana , Elena Axinte Ramona , Preda Cristina , Christina Ungureanu Maria , Mogos Voichita

Introduction: Short stature is the most common physical abnormality in Turner syndrome (TS), with adult stature averaging 20 cm shorter compared to the general population.Aim: To study the efficiency of early initiation for GH therapy on final stature for patients with Turner syndrome and to prove it’s important role in obtaining optimal growth rates.Methods: We studied a lot of 24 patients with TS diagnosed and followed up in...

ea0081p398 | Pituitary and Neuroendocrinology | ECE2022

SARS-CoV-2 infection in acromegaly patients: case series

Bilha Stefana , Matei Anca , Cristiana Istrate Andra , Leustean Letitia , Christina Ungureanu Maria , Branisteanu Dumitru D. , Preda Cristina

Introduction: SARS-Cov-2 infection challenged the appropriate management of acromegaly, because of delayed or limited admissions and treatment. Despite lack of data regarding SARS-Cov-2 infection in acromegalic patients (only one case reported to date), increased susceptibility to infection and poor prognosis might be triggered by the associated metabolic, cardiovascular and respiratory comorbidities. We report a series of acromegaly patients with a positive PCR test at their ...

ea0090p707 | Pituitary and Neuroendocrinology | ECE2023

Acromegaly and its ophthalmic, neurological and psychiatric complications

Cristiana Istrate Andra , Christina Ungureanu Maria , Leustean Letitia , Juliette Mogos Simona , Bilha Stefana , Florescu Alexandru , Preda Cristina

Introduction: Acromegaly is a rare, complex condition that throughout its evolution affects the body on numerous levels, especially if inappropriately managed. Some of the complications it develops over time are ophthalmic, neurological and psychiatric.Aim: The aim is to asses the impact of long-term acromegaly on the eye, nervous system and mental health of previously diagnosed patients.Patients and method: 90 patients’ recor...