Searchable abstracts of presentations at key conferences in endocrinology

ea0015p55 | Clinical practice/governance and case reports | SFEBES2008

Cushing’s syndrome or is it? a case report

Christodoulides Constantinos , Walker Neil , Vincent Alex , Karavitaki Niki , Wass John

A 62-year-old lady was referred to our Department with a nine-month history of facial swelling, easy bruising, and centripetal weight gain. She had a longstanding history of depression, hypertension, and osteoarthritis. She was taking citalopram, buspirone, atenolol and bendrofluazide. A few months earlier she had received bilateral intra-articular knee injections at her local hospital for arthritic pain. On examination she had thin skin with multiple bruises, facial puffiness...

ea0015p96 | Clinical practice/governance and case reports | SFEBES2008

Abbreviated metyrapone day curves: do they work?

Stoesser Nicole , Christodoulides Constantinos , Karavitaki Niki , Wass John AH

Introduction: Metyrapone is used as holding treatment in patients with CushingÂ’s syndrome awaiting definitive treatment or as adjunctive treatment following pituitary irradiation. The metyrapone day curve is used to assess the adequacy of suppression of cortisol synthesis, and in our institution involves taking four blood cortisol samples at 9 am, 12 pm, 3 pm and 6 pm respectively. A mean result between 200 and 300 nmol/l is deemed satisfactory.Aims...

ea0013p102 | Clinical practice/governance and case reports | SFEBES2007

Gastric adenocarcinoma and ectopic ACTH syndrome

Christodoulides Constantinos , Walker Neil , Karavitaki Niki , Wass John

Ectopic ACTH syndrome (EAS) is characteristically associated with neuroendocrine tumours and small cell carcinomas (SCC) typically of the bronchus. We report a rare case of EAS secondary to gastric adenocarcinoma.A 52-year old man presented to our department with a few week history of proximal myopathy, easy bruising, anxiety and weight loss. He was tanned and hypertensive. Laboratory investigations revealed hypokalaemia (2.3 mmol/l), hyperglycaemia and ...

ea0081rc10.3 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Primary bile acids differentially regulate differentiation of human abdominal and gluteal pre-adipocytes

Sabaratnam Rugivan , da Conceicao Ismael , Loh Nellie , Christodoulides Constantinos , Karpe Fredrik , Tomlinson Jeremy , Nikolaou Nikolaos

Bile acids (BAs) are synthesised from cholesterol in the liver and promote lipid digestion. An emerging body of evidence, however, suggests that BAs are also key signaling molecules with potent metabolic and endocrine functions, exerting their effects through activation of BA receptors, including the farnesoid-X- (FXR) and the G-protein-coupled- (TGR5) receptors. Disturbed BA synthesis has been associated with type 2 diabetes mellitus and insulin resistance, and recent studies...

ea0035s11.2 | Long term outcome of cured pituitary patients | ECE2014

Quality of life in patients with non-functioning pituitary adenomas

Capatina Cristina , Christodoulides Constantinos , Fernandez Alberto , Cudlip Simon , Grossman Ashley , Wass John , Karavitaki Niki

Non-functioning pituitary adenomas (NFA) are associated with significant morbidity. Published data on the quality of life (QoL) of NFA patients are scarce and conflicting: some studies indicate a reduced QoL in patients with adequately treated NFAs while others demonstrate that subjective health-related QoL is not compromised to any major extent compared to the general population. Most published studies indicate specific subgroups of patients which are particularly affected, w...

ea0028p262 | Pituitary | SFEBES2012

Quality of life in patients with non-functioning pituitary adenoma: the Oxford experience

Capatina Cristina , Christodoulides Constantinos , Fernandez Alberto , Grossmann Ashley , Wass John , Karavitaki Niki

Data on the quality of life (QoL) of patients with non-functioning pituitary adenoma (NFA) are sparse and conflicting. We have therefore evaluated the QoL in patients with NFAs followed-up in a tertiary UK referral centre and explored the impact of various factors. Three validated questionnaires (Short Form 36-SF36, Nottingham Health Profile-NHP and European Quality of Life Scale-EuroQoL) were offered to consecutive NFA subjects attending outpatient clinics over a 6-month peri...