Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep9 | Adrenal cortex (to include Cushing's) | ECE2016

The use of [131I] 6β-iodomethyl-norcholesterol scintigraphy in evaluation of adrenal tumors

Papierska Lucyna , Rabijewski Michal , Kaminska Anna , Cwikla Jaroslaw , Otto Maciej , Cichocki Andrzej , Samsel Radoslaw , Zgliczynski Wojciech

Adrenal cortex scintigraphy has been used as early as in the 1970s, however, in recent years, it has been a rarely performed and unappreciated examination. In fact, this examination does not provide a perfect view on morphology of adrenal glands, however it provides an assessment of the examined tumor’s function. The aim of this work is to present our experience with adrenal cortex scintigraphy in assessment of adrenal tumors.We present a series of ...

ea0041ep593 | Endocrine tumours and neoplasia | ECE2016

Prognostic factors of recurrence-free and overall survival in 52 patients with adrenocortical carcinoma

Nowak Karolina M. , Samsel Radoslaw , Cichocki Andrzej , Roszkowska-Purska Katarzyna , Kasperlik-Zaluska Anna , Papierska Lucyna

Adrenocortical carcinoma (ACC) is a rare and very aggressive tumor with poor prognosis. The aim of the study was to identify prognostic factors of recurrence-free (RFS) and overall survival (OS) in patients with ACC.We present a retrospective analysis in 52 patients diagnosed with ACC. A number of factors both histological and clinical were analyzed. Recurrent disease was defined as a new lesion confirmed in imaging. Kaplan-Meier method and multivariate ...

ea0022p19 | Adrenal | ECE2010

Adrenal incidentalomas accompanying malignant tumours: clinical study of 1888 patients

Kasperlik-Zaluska Anna A , Slowinska-Srzednicka Jadwiga , Roslonowska Elzbieta , Jeske Wojciech , Cichocki Andrzej , Otto Maciej , Zgliczynski Wojciech

Diagnostic procedures reveal that majority of incidentally found adrenal tumours (adrenal incidentalomas, AI) appear to be benign adenomas. However, AI accompanying malignant tumours must be diagnosed very carefully to take a proper decision concerning their management. In the registry of the Department of Endocrinology in Warsaw, there are 1888 patients (1388 women, 500 men, F/M ratio 2.8) with AI, 10–87 years old. Primary malignant tumours were diagnosed in 155 patients...

ea0020oc1.6 | Endocrine Tumours | ECE2009

Implication of the Wnt/β-catenin signaling pathway activation in the adenoma and in the malignant adrenocortical cancer

Czarnocka Barbara , Kasperlik-Zaluska Anna , Bardadin Krzysztof , Roszkowska Katarzyna , Cichocki Andrzej

The commonly expressed multifunctional protein and protooncogene β-catenin displays important functions in cell–cell adhesion and in the Wnt signaling pathway. Transforming activity of the Wnt/β-catenin pathway is thought to be involved in the development of a variety of human cancers and many β-catenin target genes have been shown to play critical functions in tumors. Therefore, the aim of this project was to determine the expression levels and cellular di...

ea0014p474 | (1) | ECE2007

Extreme obesity as an important obstacle in diagnosing a patient with MEN1

Witek Przemyslaw , Zgliczynski Wojciech , Zdunowski Piotr , Cichocki Andrzej , Cwikla Jaroslaw B.

Background: MEN1 is an autosomal dominant inherited syndrome. Primary hyperparathyroidism, tumors of the endocrine pancreas, and of the pituitary, are the characteristic features of the syndrome.Objective: To present a case of MEN1 in a patient with extreme obesity, causing serious difficulties in diagnostic procedures leading to localization of pancreatic tumors.Case presentation: 22-year-old male with extreme obesity (BMI 59), hy...

ea0056p113 | Endocrine tumours and neoplasia | ECE2018

Atypical manifestation of adrenocortical carcinoma – case series

Nowak Karolina , Lebek-Szatanska Agnieszka , Samsel Radoslaw , Cichocki Andrzej , Roszkowska-Purska Katarzyna , Zgliczynski Wojciech , Papierska Lucyna

Adrenocortical carcinoma (ACC) is a rare malignancy. Authors present three cases of even less commonly encountered manifestation of ACC. Case 1: A 39-year-old male, with decompensated hypertension, was admitted to Department of Endocrinology due to a large tumor of the left adrenal gland (65 mm) revealed in the CT of the abdomen. Non-contrast attenuation was 35HU. After performing MRI with chemical shift, tumor was classified as non-adenoma as there was no significant loss of ...

ea0020p18 | Adrenal | ECE2009

Bilateral adrenal incidentalomas – a clinical study of 1710 patients observed at a single endocrinological centre

Kasperllik-Zaluska Anna , Slowinska-Srzednicka Jadwiga , Roslonowska Elzbieta , Kochman Magdalena , Zgliczynski Wojciech , Jeske Wojciech , Otto Maciej , Cichocki Andrzej

In the last 18 years 1710 patients with incidentally found adrenal tumours=adrenal incidentalomas (AI), 1300 women (F/M=2.8), aged 10–87 years, were registered at our department. In 338 of them (20%) bilateral tumours were detected. This study aimed at analyzing character of bilateral tumours and defining methods of their management. The size: 1.0–13 cm (in the group of 1710 patients: 1.0–23 cm) most of them up to 3.5 cm. Hormonal and imaging studies were perfor...

ea0035p557 | Endocrine tumours and neoplasia | ECE2014

Adrenal incidentaloma: is it a disease of elderly? A clinical study of 2650 cases registered at a single endocrinological center

Kasperlik-Zaluska Anna , Otto Maciej , Cichocki Andrzej , Slapa Rafal , Rozkowszka Katarzyna , Slowinska-Srzednicka Janina , Roslonowska Elzbieta , Jeske Wojciech , Zdunowski Piotr , Zgliczynski Wojciech

It is generally believed that frequency of incidentally found adrenal tumours (adrenal incidentaloma(AI)) increases with age. Our study aimed at an analysis of age patterns in our group of patients with AI.Design: Material: 2650 patients, 1943 womens, 707 men. The diagnostic basis: clinical examination, imaging studies, hormonal determinations, pathomorphological and cytochemical investigations of the surgically removed 755 adrenal tumours. The material ...

ea0014p133 | (1) | ECE2007

Adrenal incidentaloma, an oncological or endocrinological enigma? Clinical analysis of 1300 cases observed at a single endocrinological centre

Kasperlik-Zaluska Anna , Roslonowska Elzbieta , Slowinska-Srzednicka Jadwiga , Zgliczynski Wojciech , Jeske Wojciech , Papierska Lucyna , Otto Maciej , Slapa Rafal , Cichocki Andrzej , Cwikla Jaroslaw

Objective: Incidentally found adrenal tumour (adrenal incidentaloma = AI) is the most frequent adrenal disorder. Every patient with AI has to be evaluated carefully to choose the best method of management. We present our experience with a group of 1300 patients with AI, registered at our department.Material and methods: Material consisted of 1300 patients (female/male ratio 2.6, age 10–87 years) with AI ranging in size from 0.8 to 23.0 cm. Methods: ...

ea0052p17 | (1) | UKINETS2017

Surgical therapy for appendiceal neuroendocrine tumours: is appendicectomy adequate?

Clift Ashley , Pawa Nikhil , Drymousis Panagiotis , Cichocki Andrzej , Flora Rashpal , Goldin Rob , Patsouras Dimitrios , Baird Alan , Malczewska Anna , Kinross James , Faiz Omar , Antoniou Anthony , Wasan Harpreet , Kaltsas Gregory , Darzi Ara , Cwikla Jaroslaw , Frilling Andrea

Background: Neuroendocrine tumours of the appendix (ANET) are relatively indolent tumours typically identified incidentally at surgery for suspected appendicitis. The role of right hemicolectomy (RH) for tumours with ‘high risk’ features is debated. We compared the management of ANET at three centres against ENETS criteria for therapy selection.Methods: Retrospective review of all patients diagnosed with ANET at three tertiary centres. Patients...